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Harmful effects to the liver and reproductive effects due to repeated exposure are considered to be the critical health effects in the risk assessment of DIDP and DINP. Risks are assessed by comparing worst case exposures to the exposures at which no harmful effects were observed in animal studies.

In laboratory animals the main effects of DIDP and DINP are on the liver and include cancer. Humans are thought to be much less sensitive to these liver effects and the cancer is caused by a mechanism which is only seen in rodents and not in humans. DIDP and DINP also affect survival of rat offspring.

DiDP can make your eyes and skin red or cause nausea, dizziness, and vomiting. DINP causes tumors and developmental problems in lab rats. In 2014, California added it to its list of chemicals

The Agency has also proposed adding one class of phthalates—DINP—to its toxic chemicals list because “because the members of the category can reasonably be anticipated to cause cancer and serious or irreversible chronic health effects in humans; specifically, developmental, kidney, and liver toxicity.”

development effects –DIDP: negligible concern for adverse reproductive effects and minimal concern for adverse development effects DINP and DIDP are not selective reproductive or developmental toxins DINP and DIDP are not endocrine disrupters: Weybridge definition, International Programme for Chemical Safety, and REACH