5. What health effects can DIDP and DINP cause in laboratory
DIDP showed a very slow excretion, reflecting a slow dermal uptake process. The maximum percentage of absorption may be estimated 4% of applied dose in 7 days by analogy with DINP. In humans, skin absorption is still lower than in rat as indicated by in vitro comparative studies.
Phthalate Di-isodecyl & Di-isononyl phthalates - GreenFacts
In laboratory animals the main effects of DIDP and DINP are on the liver and include cancer. Humans are thought to be much less sensitive to these liver effects and the cancer is caused by a mechanism which is only seen in rodents and not in humans. DIDP and DINP also affect survival of rat offspring.
DINP and DIDP - U.S. Consumer Product Safety Commission
minimal concern for adverse development effects DINP and DIDP are not selective reproductive or developmental toxins DINP and DIDP are not endocrine disrupters: Weybridge definition, International Programme for Chemical Safety, and REACH DINP and DIDP do not pose a risk to male reproductive tract development
High Phthalates - Chemical Safety Facts
High phthalates, such as diisononyl phthalate (DINP) and diisodecyl phthalate (DIDP), have been thoroughly studied and reviewed by a number of government scientific agencies and regulatory bodies world-wide, which have concluded that phthalates used in commercial products do not pose a risk to human health at typical exposure levels.
Multi-pathway human exposure assessment of phthalate esters
Show abstract. 1,2-Cyclohexane dicarboxylic acid, diisononyl ester (DINCH) is a complex mixture of nine carbon branched-chain isomers. It has been used in Europe since 2002 as a plasticizer to replace phthalates such as di (2-ethylhexyl)phthalate (DEHP) and diisononyl phthalate (DINP).
