EFFECT OF POLYMER AND PLASTICIZER ON THIN POLYMERIC BUCCAL
Aim of the present work was to design fast dissolving buccal film of meloxicam using central composite rotatable design and to evaluate the effects of polymer and plasticizer on formulation and characterization of the buccal films.
EFFECT OF POLYMER AND PLASTICIZER ON THIN POLYMERIC BUCCAL
Aim of the present work was to design fast dissolving buccal film of meloxicam using central composite rotatable design and to evaluate the effects of polymer and plasticizer on formulation and characterization of the buccal films. Meloxicam was incorporated in film as model drug, HPMC E15 was used
Effect of polymer and plasticizer on thin polymeric buccal
Findings have been advocating the effects of polymer and plasticizer in such a way that there was a gradual increase in dissolution time by increasing polymeric contents and decrease with...
Optimization and evaluation of instant release buccal films
Concentrations of polymer (HPMC E5), plasticizer (glycerin), and stirring time were selected as variables, while the concentration of remaining ingredients includes Tween 80 (3 ml) and solution of the drug; eletriptan 20 mg was kept constant in all the formulations. Preparation of eletriptan IRBFs using the solvent casting technique
EFFECT OF POLYMER AND PLASTICIZER ON THIN POLYMERIC BUCCAL
posite rotatable design and to evaluate the effects of polymer and plasticizer on formulation and characteriza- tion of the buccal films. Meloxicam was incorporated in film as model drug, HPMC E15
- Which polymers increase the mucoadhesive properties of buccal films?
- In the present work, four different polymers were examined for their ability to increase the mucoadhesive properties of buccal films, namely: chitosan, polyacrylic acid (PAA), sodium alginate (SA), and polyvinylpyrrolidone (PVP).
- Does plasticizer affect mucoadhesive properties?
- A further reduction was measured in samples OTF 2.5 and OTF 3 containing 71 and 75% w/w of glycerol respectively. It is likely that the excess of plasticizer prevented the polymer from interpenetrating and interacting with mucin, thus negatively affecting the mucoadhesive properties of the final formulation.
- What polymers are used for fast dissolving oral thin film?
- In this review article the different polymers used for preparation of fast-dissolving oral thin film like Pullulan, Gelatin, Sodium Alginate, Pectin, Rosin, Starch, Chitosan are discussed together with their physicochemical properties and film forming properties. Keywords: Fast dissolving films, Oral thin films, plasticizers, polymers.
- How does glycerol affect the mechanical properties of final films?
- The mechanical properties of the final films were influenced by the amount of glycerol included in the formulation.
- Can deacylated gellan gum and plasticizer glycerol be used to make thin films?
- In this work, deacylated gellan gum and the plasticizer glycerol were used as primary components for the preparation of thin films intended for the oral delivery of therapeutic molecules.
- Can gellan gum-based thin films be used for buccal drug delivery?
- Overall, these results indicate that gellan gum-based thin films can be potentially used for buccal drug delivery upon precise selection of the appropriate concentration of glycerol used as a plasticizer. 1. Introduction
