Effect of subacute and prenatal DINCH plasticizer exposure on
In the present study, we collected tissues from dams exposed subacutely and progeny at postnatal day (PND) 3 and 60 exposed in utero to DINCH (1, 10 and 100 mg/kg bw/day). Exposure to DINCH drastically affected liver gene expression in all 3 age groups tested and in particular at the dose of 1 mg/kg bw/day.
Effect of subacute and prenatal DINCH plasticizer exposure on
Exposure to DINCH drastically affected liver gene expression in all 3 age groups tested and in particular at the dose of 1 mg/kg bw/day. The PPAR-α pathway along with other metabolic and DNA replication pathways were affected by DINCH.
Effect of subacute and prenatal DINCH plasticizer exposure on
DINCH and MINCH induced cellular stress and pro-inflammatory effects in macrophages, which may lead to adverse health effects, and were associated with oxidative stress, mitochondrial dysfunction, DNA damage repair, apoptosis, and autophagy. 10 PDF View 2 excerpts, cites background
Effect of prenatal DINCH plasticizer exposure on rat
This observation suggests that the effect of DINCH could be related to premature aging of the testis. It is noteworthy that of 13 control animals and animals exposed to 100 mg DINCH/kg/day,...
Rebuttal to Comment on “Alternative Plasticizers As Emerging
DINCH (di-isononyl cyclohexane-1,2-dicarboxylate) is a non-phthalate plasticizer that has been developed to replace phthalate plasticizers such as DEHP (di-2-ethylhexyl phthalate) or DINP (di
- Does DINCH pose a risk to humans?
- In fact, the biological translation of our rat in vivo results reveals that DINCH might pose a risk to humans because it affects many hepatic gene pathways and therefore, it might affect liver function, as well as general body homeostasis.
- Does DINCH affect gene expression?
- Subacute exposure to DINCH alters gene expression in gestational day (GD) 21 (Panels A, B, and C) and postnatal day (PND) 21 dams (Panels D, E, F and G) without direct liver toxicity.
- Is DINCH cytotoxic?
- Additionally, a recent study from Vasconcelos et al. demonstrated as well that DINCH is cytotoxic for human renal proximal tubule epithelial cells (HK-2) and can cause transient oxidative DNA damage in human hepatocarcinoma cells (HepG2) ( Vasconcelos et al., 2019 ).
- How do phthalate plasticizers affect the endocrine system?
- Endocrine disruption is achieved through specific effects of phthalate plasticizers either on several nuclear receptors (e.g. androgen receptor, estrogen receptor, thyroid receptors and peroxisome proliferator activated receptors [PPARs]) or through modification in hormone formation ( Gibson, 1993; Gore et al., 2015).
