Effects of plasticizers and surfactants on the film forming
The quality of the aqueous film coats or the plasticizer efficiency in case of PEG-400 is in the order 1.5 > 0.5 > 1.0% and for PG 1 > 4 > 3% which can be stated on the basis of less incidence...
Effects of plasticizers and surfactants on the film forming properties
The quality of the aqueous film coats or the plasticizer efficiency in case of PEG-400 is in the order 1.5 > 0.5 > 1.0% and for PG 1 > 4 > 3% which can be stated on the basis of less incidence of major coat defects like chipping, cracking, orange peel, roughness, blistering, blooming, picking.
[PDF] Effects of plasticizers and surfactants on the film forming
Effects of plasticizers and surfactants on the film forming properties of hydroxypropyl methylcellulose for the coating of diclofenac sodium tablets. A. Roy, Amitava Ghosh, +4 authors M. E. Bhanoji Rao Published 1 July 2009 Materials Science Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
Effects of plasticizers and surfactants on the film forming properties
Effects of plasticizers and surfactants on the film forming properties of hydroxypropyl methylcellulose for the coating of diclofenac sodium tablets AmitavaRoya AmitavaGhosha SupriyaDattaa SujitDasa P.Mohanraja JyotirmoyDeba M.E.Bhanoji Raob Add to Mendeley https://doi.org/10.1016/j.jsps.2009.08.004 Get rights and content
EFFECTS OF PLASTICIZERS AND SURFACTANTS ON THE FILM FORMING PROPERTIES
Saudi Pharmaceutical Journal, Vol. 17, No. 3 July 2009 EFFECTS OF PLASTICIZERS AND SURFACTANTS ON THE FILM FORMING ... To ensure spreading and/or film forming capability plasticizers are added.
- Which plasticizers are used in aqueous based film coating formulation?
- Proper optimization for the aqueous based film coating formulation was undertaken primarily employing plasticizers like polyethylene glycol (PEG) 400 and propylene glycol (PG).
- Do Surfactants affect mechanical properties?
- In the absence of glycerol, surfactants had a significant effect on mechanical properties, but they did not modify significantly WVP of the films. It was observed a synergistic behavior between the plasticizer and the surfactants.
- How do plasticizers affect film properties?
- The type and concentration of plasticizers can affect the film properties, as revealed by several investigations ( Mortada, 1990, Siepmann et al., 2005, James, 1997 ). The plasticizing efficiency is measured by the lowering of the incidence of coat defects.
- Do plasticizers and surfactants have a synergistic effect?
- Results were different when we studied the effect of both additives at the same time, that is, plasticizers and surfactants ( Fig. 5 ). As we observed for mechanical properties, an apparent synergistic effect between both components is shown, appreciable for low and high level of surfactants.
- Which surfactant reduces wettability of film solutions?
- The wettability of the film solutions was quantified by measuring their surface tension. The incorporation of plasticizers resulted in more flexible and manageable films and higher WVP. At low concentration, Tween 20 was the surfactant that reduced surface tension the most, while at high concentration it was lecithin.
- Does plasticizer influence the quality of aqueous film coats?
- This preliminary study infers that plasticizer significantly influences the quality of aqueous film coats. The best formulations (F3 and F4) are selected for further trials. Two surfactants of high HLB value namely SLS and Tween-80 were tried for bringing uniformity in the spreading efficiency on the substrate surface.
