Identifying Greener and Safer Plasticizers: A 4-Step Approach
step 2: cell and ex vivo-based approaches to determine the toxicity of alternative plasticizer chemicals Immortalized Cell Lines A cell-based toxicity screening approach was used to select the most promising alternative plasticizers among the range of chemicals previously tested for their plasticizing properties, biodegradability, and leachability.
Evaluation of Alternative Plasticizers for Surelease, an Aqueous
Evaluation of Alternative Plasticizers for Surelease, an Aqueous Ethylcellulose Dispersion for Modified Release Film-Coating Authors: Charles F. Vesey Thomas Farrell Ali Rajabi-Siahboomi...
Plasticizers for Surelease - ResearchGate
Evaluation of Alternative Plasticizers for Surelease, an Aqueous Ethylcellulose Dispersion for Modified Release Film-Coating Charles F. Vesey , Thomas Farrell, Ali R. Rajabi-Siahboomi
Dose reconstruction of four alternative plasticizers from urinary
The surface of each product was wiped with three dry and three wet (by isopropanol) cotton wipes, so as to evaluate the mass transfer of plasticizers to clothing and human skin, respectively....
Science of the Total Environment - Department of Environmental Science
The aim of this review is to evaluate current substance classes of alternative plasticizers, and in particular: 1. Provide and discuss information on physicochemical properties, production volume, use, emissions, indoor fate, human exposure and health concerns of alternative plasticizers. 2. Address their human risk potential and their persistent/
- Does surelease control the release of microparticles?
- Surelease was unable to efectively control the release in the form of microparticles; however, it has been able to control the release in a compacted form . Kazlauske et al. evalu-ated the surelease E-7–19020 on the theophylline-coated pellets.
- Can surelease E-7 19010 be used to prepare controlled-release microparticles?
- Surelease E-7–19010 was also used to prepare controlled-release microparticles using spray-drying process. Surelease was unable to efectively control the release in the form of microparticles; however, it has been able to control the release in a compacted form .
- How is Dibutyl sebacate a plasticizer?
- Dibutyl sebacate at 10%w/w with respect to the polymer was added as a plasticizer. Drug-layered Suglets were then coated to 5% and 15%w/w weight gain with the plasticized ethylcellulose solutions. In all coating trials, the process attributes such as dew point control, atomization pressure, spray rate, and product temperature were kept constant.
- Which plasticizers are compatible with ethylcellulose?
- The Glass transition temperature (T g ) and Solubility Parameters of ethylcellulose are 130.0°C and 20.0 MPa 0.5 , respectively . Veset et al. showed that except glycerin, polyethylene glycol 400, and propylene glycol, other plasticizers listed were compatible with the ethylcellulose. ... ...
- Does surelease clear have a seal coat?
- Surelease clear has an alkaline pH, and the seal coat prevents direct exposure of the core to the alkaline coating dispersion. Core tablets from a batch size of 10,000 units were divided into 2 parts, and the seal coat-ing was carried out in 2 lots.
- Does water soluble plasticizer leach out?
- During dissolution studies, the water-soluble plasticizer may leach out and may impact the permeability and mechanical properties of the film [41, 42]. On the other hand, leaching of water-insoluble plasticizers expected to be lower due to their low aqueous solubility.
