Evaluation of the Direct Toxicity of Trioctyltrimellitate
To evaluate the possible toxic liver risk resulting from exposure to DEHP and TOTM, isolated rat hepatocytes were incubated with either DEHP, TOTM, MEHP or their common metabolite (2-EH) for...
Evaluation of the direct toxicity of trioctyltrimellitate
Because of the suspected toxicity of DEHP, an alternative plasticizer, trioctyltrimellitate (TOTM) has aroused increasing interest. The aim of this study was to determine on isolated rat hepatocytes in vitro, the direct hepatotoxic potential of both DEHP and TOTM and their hydrolytic products.
Evaluation of the direct toxicity of trioctyltrimellitate
Evaluation of the direct toxicity of trioctyltrimellitate (TOTM), di(2-ethylhexyl) phthalate (DEHP) and their hydrolysis products on isolated rat hepatocytes.
CPSC Staff Statement on University of Cincinnati Report
TOXICITY REVIEW FOR . TRIOCTYLTRIMELLITATE (TOTM) Contract No. CPSC-D-17-0001 . Task Order No. 003 . Prepared by: Risk Science Center . Department of Environmental Health . University of Cincinnati . 160 Panzeca Way, Room G24 . Cincinnati, OH 45267 . Prepared for: Kent R. Carlson, Ph.D. U.S. Consumer Product Safety Commission . 4330 East West
Sci-Hub | Evaluation of the Direct Toxicity
Evaluation of the Direct Toxicity of Trioctyltrimellitate (TOTM), di(2-ethylhexyl) Phthalate (DEHP) and their Hydrolysis Products on Isolated Rat Hepatocytes.
- What is trioctyltrimellitate (TOTM)?
- Trioctyltrimellitate (TOTM) is trimellitate plasticizers which exhibits a low potential of toxicity due to its relative higher molecular weight and bulky side chains. TOTM has unique low leaching and extraction resistance that are required for medical tubing. TOTM leaching properties is about thirty times less than DEHP.
- Does TOTM cause toxicity in general?
- In the studies conducted, TOTM caused only minimal signs of toxicity. The primary effects noted in the systemic toxicity studies were peroxisome proliferation and related effects in the liver (CMA, 1986, 1987; Hodgson, 1987). Males were more sensitive than females to peroxisome proliferation. However, the passage does not directly answer whether TOTM causes toxicity in all cases or under all conditions. It only mentions the findings from specific studies.
- Is TOTM a toxicokinetic drug?
- The toxicokinetics of TOTM have primarily been studied in a single report where TOTM, radiolabeled on the 2-carbon atom of a 2-ethylhexyl group, was administered to male SD rats by gavage in corn oil at 100 mg/kg (Eastman Kodak Co., 1984a, as cited by Versar, 2010; OECD, 2002; ECHA, 2018).
- Is TOTM a peroxisome proliferator?
- According to the report, TOTM appears to be a peroxisome proliferator. Despite producing effects similar to DEHP in a 28-day oral rat study (CMA, 1986; Hodgson, 1987), TOTM was much less potent.
- How toxic is Kodak TOTM when heated?
- Eastman Kodak Co. reported much higher toxicity for Kodak TOTM in a study where the solution was heated to 180oC (U.S. EPA, undated; ECHA, 2018). In contrast, the low toxicity with the TOTM aerosol is not mentioned in this context.
- Is TOTM toxic for albino white rabbits?
- In a GLP-compliant study, there were no signs of toxicity, body weight changes, or death in a group of 3 male and 3 female New Zealand albino white rabbits when 2.0 mL/kg of TOTM (1970 mg/kg, based on a density of 0.985 g/cm3) was applied to their abraded skin.
