SKF-83566 | Dopamine D1/D5 Receptor Antagonist | MedChemExpress
SKF-83566 is a potent, blood-brain permeable and orally active D1-like dopamine receptor (D1DR) antagonist and a weaker competitive antagonist at the vascular 5-HT2 receptor (Ki=11 nM). SKF-83566 is a competitive DAT (dopamine transporter) inhibitor with an IC50 of 5.7 μM. SKF-83566 also shows selective inhibition for adenylyl cyclase 2 (AC2) over AC1 and AC5 in the isolated rabbit thoracic
D1 and D5 Receptor Antagonists - Tocris Bioscience
D 1 and D 5 Receptor Antagonists View all D 1 and D 5 Receptor products Related Targets D 2 Receptors D 3 Receptors D 4 Receptors Dopamine Transporters Monoamine Oxidases Distributor Information Your territory is served exclusively by our distributor network.
CVL-871 - Cerevel Therapeutics
About the Mechanism of CVL-871. Dopamine acting on D1/D5 receptor subtypes in the cortex and midbrain plays a key role in the finely-tuned and dynamic neural network that modulates cognitive function, reward-processing and decision-making. Conscious goal-directed behavior is mediated by the mesolimbic dopamine pathway. D1 receptors in non-motor
D5 receptor inhibitor | D5 receptor inhibition
SCH-23390 hydrochloride (R-(+)-SCH-23390, SCH-23390) is a highly potent and selective dopamine D1-like receptor antagonist with Ki of 0.2 nM and 0.3 nM for the D1 and D5 dopamine receptor subtypes, respectively. SCH-23390 hydrochloride is a potent and high efficacy agonist at h5-HT2C receptors with Ki of 9.3 nM.
Mechanisms of D1/D2-like dopaminergic agonist
Rotigotine ([-]2-(N-propyl-N-2-thienylethylamino)-5-hydroxytetraline) is a dopamine agonist with an affinity for all dopamine receptors (D1 to D5), which when delivered daily as a single dose
