Plasticizer Interaction With the Heart | Circulation: Arrhythmia and
Plasticizer Interaction With the Heart Chemicals Used in Plastic Medical Devices Can Interfere With Cardiac Electrophysiology Rafael Jaimes III , Damon McCullough , Bryan Siegel , Luther Swift , Daniel McInerney , James Hiebert , Erick A. Perez-Alday , Beatriz Trenor , Jiansong Sheng , Javier Saiz , See all authors
Plasticizer Interaction With the Heart: Chemicals Used in Plastic
Heightened clinical exposure to plasticized medical products may have cardiac safety implications-given that action potential triangulation and electrical restitution modifications are a risk factor for early after depolarizations and cardiac arrhythmias. Keywords: action potentials; electrophysiology; heart; plasticizer; plastics.
Plasticizer Interaction With the Heart: Chemicals Used in Plastic
Plasticizer Interaction With the Heart: Chemicals Used in Plastic Medical Devices Can Interfere With Cardiac Electrophysiology. Jaimes R 3rd1, McCullough D1, Siegel B2, Swift L1, McInerney D1, Hiebert J1, Perez-Alday EA3, Trenor B4, Sheng J5, Saiz J1, Tereshchenko LG3, Posnack NG1 Author information Affiliations 7 authors 1.
What Effects Do Plasticizers Have on the Heart?
A preclinical study, entitled "Plasticizer Interaction With the Heart," appears in the July issue of Circulation: Arrhythmia and Electrophysiology and examines the role plastic exposure, akin to exposure in a medical setting, has on heart rhythm disruptions and arrhythmias.
Abstract 454: Plasticizer Interaction With the Heart: Chemicals Used
Background: Phthalates are employed as plasticizers in the manufacturing of flexible, plastic medical products. Patients can be subjected to high phthalate exposure through contact with plastic med...
- Can plasticizers interfere with cardiac electrophysiology?
- Jaimes, R. et al. Plasticizer interaction with the heart: chemicals used in plastic medical devices can interfere with cardiac electrophysiology. Circ. Arrhythmia Electrophysiol. 12, e007294 (2019). The author is supported by the NIH (R01HL139472) and the Children’s Heart Institute.
- Are plasticizers a risk factor for cardiac arrhythmias?
- Heightened clinical exposure to plasticized medical products may have cardiac safety implications-given that action potential triangulation and electrical restitution modificationsare a risk factor for early after depolarizations and cardiac arrhythmias. Keywords: action potentials; electrophysiology; heart; plasticizer; plastics.
- Are phthalates a plasticizer?
- Background:Phthalates are used as plasticizers in the manufacturing of flexible, plastic medical products. Patients can be subjected to high phthalate exposure through contact with plastic medical devices.
- Are plastics a risk factor for cardiovascular disease?
- Nature Reviews Cardiology 18 , 69–70 ( 2021) Cite this article Plastics are synonymous with modern life. Nevertheless, the ubiquity of plastics has resulted in their continuous exposure to humans, which can be harmful. The available literature suggests that this daily exposure might be contributing to cardiovascular disease.
- Are Plasticizer additives harmful to humans?
- Plastics are indispensable materials; however, their ubiquity has raised concerns about the continuous exposure of humans to plastics. To date, these concerns are primarily directed towards plasticizer additives, such as di (2-ethylhexyl) phthalate (DEHP) and synthetic chemicals used to create polymers, such as bisphenol A (BPA).
- How does phthalate affect heart function?
- Acute exposure to DEHP or its main metabolite, mono (2-ethylhexyl) phthalate, decreases coronary flow and systolic tension in rat intact heart preparations and decreases contractile function in atrial tissue preparations. Moreover, phthalate treatment slows heart rate, atrioventricular conduction and epicardial conduction velocity 10.
