Plasticizer Excipients, Inert Pharmaceutical Ingredients

                                               
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Featured excipient: Plasticizers - The Medical Dictionary

                                               
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  • What is a primary plasticizer?
  • A primary plasticizer enhances elongation, softness and flexibility of polymer. They are highly compatible with polymers and can be added in large quantities. For example: up to 50% of vinyl gloves are made up of plasticizers, which make the PVC flexible and soft enough to wear.
  • How are excipients manufactured?
  • Excipients are often manufactured on a large scale utilising continuous processing and automated process controls. Production equipment and processes vary depending on the type of excipient being produced, the scale of production and the type of operation (for example batch versus continuous process).
  • What are natural product type plasticizers?
  • Vegetable oil derivatives are the most widely used natural product type plasticizers. Products consisting of triglyceride esters of unsaturated fatty acids (e.g., soybean oil, linseed oil) in which the double bonds in the fatty acid residues have typically been epoxidized have been commercial products for decades.
  • How are plasticizers classified?
  • Plasticizers are classified based on their chemical composition. It is important to understand the influence of structural elements on the properties of plasticizers and their effect on base polymers. For example, the presence of elements like alcohols in a homologous series of phthalates, and adipates.
  • What standards are used in the manufacture of excipients?
  • Reference is made to other publications and standards, such as the EXCiPACT GMP and GDP or NSF/IPEC/ANSI-363 2014 standards. The manufacture of certain excipients for specialist applications presents additional challenges that are outside of the scope of this Guide. Examples include excipients; that are sterile and/or pyrogen free.
  • What are plasticizers & how do they work?
  • Plasticizers are non-volatile organic substances (mainly liquids) added into a plastic or elastomer. They are also usually cheaper than other additives. They improve the following properties of the polymers: Plasticizers increase the flow and thermoplasticity of a polymer.