Guideline on the use of phthalates as excipients in human
Phthalates are used as functional excipients in a large number of oral pharmaceutical formulations. They are most commonly used as plasticizing agents in enteric film -coating materials or as a matrix binder for tablets, capsules, beads and granules. Due t o their plasticizer properties, phthalates can be
Plasticizer Excipients | American Pharmaceutical Review
Plasticizer Excipients Plasticizers are used mainly for oral solid dosage forms. Plasticizers are added to the polymers used as film forming agents in order to make the polymer pliable and soft, enhancing the flexibility and plasticity of the films.
Impact of formulation excipients on the thermal, mechanical
This research focused on how plasticizers and surfactants, excipients used for aqueous coating, affect the properties and stability of HPMCAS. This information would be useful in identifying suitable excipients for developing a stable HPMCAS aqueous enteric coating formulation.
Featured excipient: Plasticizers - The Medical Dictionary
Triacetin: Featured excipient: Plasticizers at The Medical Dictionary Triacetin The triglyceride 1,2,3-triacetoxypropane is more generally known as triacetin and glycerin triacetate. The structural formula is It is an artificial chemical compound, commonly used as food additive with European cq.
Plasticizer Excipients - CD Formulation
DEHP (bis (2-ethylhexyl) phthalate) is a commonly used plasticizer. It is very toxic in small doses, but long-term large-scale exposure can cause many health problems. Many tablets have film coating. This is to protect the active ingredients in the tablet. A layer of coating separates the tablet core from the outside air and humidity.
- What is a pharmaceutical excipient?
- 32.1. Introduction to excipients A pharmaceutical excipient by definition is a substance or a group of substances that add suitable volume and ensure content uniformity, which serves as a vehicle and incorporates the active pharmaceutical ingredient (API) in the formulation.
- What are the excipients used in chemistry?
- The excipients used are polysorbates, poloxamers, PEGs, propylene glycol, and EDTA. 32.6.4. Tonicity agents
- Are excipients just a 'inert and low-priced vehicle?
- There has been a paradigm shift in considering excipients as just an “inert and low-priced” vehicle to a crucial component in the design and development of pharmaceutical formulations.
- Which chelating agent is used in parenteral preparations?
- The commonly used ones are ascorbic acid, acetylcysteine, sodium ascorbate, sodium metabisulfite, sodium bisulfite, and tocopherol. Chelating agents are chemical compounds that react with metal ions to form a stable, water-soluble complex thereby preventing catalysis of oxidation reaction. The only one used in parenteral preparations is EDTA.
- What are coprocessed excipients?
- Hence, coprocessed excipients were introduced (Shah et al., 2016). Coprocessing is a novel concept that alters excipient functionality by retaining favorable attributes and supplementing with newer ones, by processing parent excipient with another excipient (Garg et al., 2013). Some of them are enlisted: 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 32.2.17.
- Do excipients make a good formulation?
- Excipients form an integral part of the formulation. It is now well realized that a combination of good science and good judgment is necessary for appropriate selection of excipients to fabricate a successful formulation.
