Plasticizer Interaction With the Heart | Circulation
Di-2-ethylhexyl phthalate (DEHP) is the most commonly used plasticizer in Food and Drug Association–approved medical devices, including blood storage bags, tubing circuits, enteral feeding tubes, endotracheal tubes, and catheters. 4 In the finished product, DEHP can contribute up to 40% by weight in intravenous bags and 80% by weight in medical
Plasticizer Interaction With the Heart: Chemicals Used
Heightened clinical exposure to plasticized medical products may have cardiac safety implications-given that action potential triangulation and electrical restitution modifications are a risk factor for early after depolarizations and cardiac arrhythmias. Keywords: action potentials; electrophysiology; heart; plasticizer; plastics.
Abstract 454: Plasticizer Interaction With the Heart
Background: Phthalates are employed as plasticizers in the manufacturing of flexible, plastic medical products. Patients can be subjected to high phthalate exposure through contact with plastic med...
[PDF] Plasticizer Interaction With the Heart | Semantic Scholar
Plasticizer Interaction With the Heart Rafael Jaimes, Damon McCullough, +9 authors N. Posnack Published 28 June 2025 Medicine, Biology Circulation. Arrhythmia and Electrophysiology Background: Phthalates are used as plasticizers in the manufacturing of flexible, plastic medical products.
Plasticizer interaction with the heart - Medical Xpress
New preclinical research finds acute exposure to MEHP, a common plasticizer used in medical equipment, increases risk for alternans and arrhythmias, disruptions in heart rhythm. The images...
- Are plasticizers a risk factor for cardiac arrhythmias?
- Heightened clinical exposure to plasticized medical products may have cardiac safety implications-given that action potential triangulation and electrical restitution modificationsare a risk factor for early after depolarizations and cardiac arrhythmias. Keywords: action potentials; electrophysiology; heart; plasticizer; plastics.
- Can plasticizers interfere with cardiac electrophysiology?
- Jaimes, R. et al. Plasticizer interaction with the heart: chemicals used in plastic medical devices can interfere with cardiac electrophysiology. Circ. Arrhythmia Electrophysiol. 12, e007294 (2019). The author is supported by the NIH (R01HL139472) and the Children’s Heart Institute.
- Does plastic cause heart disease?
- NYU Langone study linked exposure to phthalate chemicals found in plastic to more than 356,000 global deaths from heart disease in 2018 alone. Learn more.
- Are phthalates a plasticizer?
- Background:Phthalates are used as plasticizers in the manufacturing of flexible, plastic medical products. Patients can be subjected to high phthalate exposure through contact with plastic medical devices.
- Are Plasticizer additives harmful to humans?
- Plastics are indispensable materials; however, their ubiquity has raised concerns about the continuous exposure of humans to plastics. To date, these concerns are primarily directed towards plasticizer additives, such as di (2-ethylhexyl) phthalate (DEHP) and synthetic chemicals used to create polymers, such as bisphenol A (BPA).
- How does BPA affect the heart?
- For example, BPA exposure disrupts myocardial calcium signalling, which is an important regulator of electrical activity, contractile function and vasoactivity. Acute exposure to BPA inhibits voltage-gated calcium channels and impairs intracellular calcium dynamics in rodent cardiomyocytes and ex vivo rodent heart tissue.
