Non-phthalate plasticizer DEHT preserves adequate blood
Our study demonstrates that the plasticizer DEHT provides adequate blood component quality. We propose DEHT as a strong future candidate for replacement of DEHP in blood bags. Non-phthalate plasticizer DEHT preserves adequate blood component quality during storage in PVC blood bags Vox Sang. 2025 Jan;116(1):60-70.doi: 10.1111/vox.12982.
Bis(2-ethylhexyl) phthalate
DEHP is the most common phthalate plasticizer in medical devices such as intravenous tubing and bags, IV catheters, nasogastric tubes, dialysis bags and tubing, blood bags and transfusion tubing, and air tubes. DEHP makes these plastics softer and more flexible and was first introduced in the 1940s in blood bags.
DEHT is a suitable plasticizer option for phthalate-free storage
Di (2-ethylhexyl) terephthalate (DEHT) provides sufficient red blood cell (RBC) quality during conventional blood bank storage. It is important that a new plasticizer also maintains acceptable quality during exposure to high cell stress, such as irradiation, which is commonly used to prevent graft-versus-host disease.
Plasticizers: Types, Uses, Classification, Selection & Regulation
DEHP offers good gelling, satisfactory electrical properties and helps to produce highly elastic compounds with reasonable cold strength. It displays fairly good flexibility at low temperatures and some resistance to high-temperature. However, DEHP is listed by the IARC as a human carcinogen.
What is DEHP? Where is it used? Why is it used? | U.S. Plastic
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- Why is DEHP used in plasticization and processing of PVC?
- The excellent performance of DEHP in the plasticization and processing of PVC explains its wide use in medical devices over the past few years. The strategy was to adjust the chemical nature of the lateral alkyl chains in order to reduce the leaching of the plasticizers into the surrounding medium.
- Are there alternatives to DEHP?
- MD manufacturers were therefore forced to quickly find alternatives to DEHP to maintain the elasticity of PVC nutrition tubings, infusion sets and hemodialysis lines. Several replacement plasticizers, so-called “alternative to DEHP plasticizers” were incorporated into the MDs.
- Which phthalate plasticizer is used in medical devices?
- DEHP is the most common phthalate plasticizer in medical devices such as intravenous tubing and bags, IV catheters, nasogastric tubes, dialysis bags and tubing, blood bags and transfusion tubing, and air tubes. DEHP makes these plastics softer and more flexible and was first introduced in the 1940s in blood bags.
- Which plasticizers are used in MDS?
- The review focuses on the aternative to DEHP plasticizers currently used in the MDs. Their migration from PVC depends partially on their physicochemical properties. The patient׳s exposure is the main risk and has to be investigated. Appropriate analytical methods are developed to quantify them in different matrices.
- Which plasticizer is most commonly used?
- Di- (2-ethylhexyl)-phthalate (DEHP) has been the most widely used plasticizer since its introduction in 1930. However, the non-covalent bond between DEHP (or plasticizers in general) and polymers mean they can be leached when they enter into contact with fluids containing lipophilic compounds .
- What is DEHP used for?
- Due to its suitable properties and the low cost, DEHP is widely used as a plasticizer in manufacturing of articles made of PVC. Plastics may contain 1% to 40% of DEHP. It is also used as a hydraulic fluid and as a dielectric fluid in capacitors. DEHP also finds use as a solvent in glowsticks.
