Guideline on the use of phthalates as excipients in human
Dibutyl phthalate (DBP) DBP was associated with an anti-androgenic effect in a human cell line as it inhibited the binding of dihydrotestosterone to the androgen receptor with an IC 50 of 74 M (Christen et al. 2010). DBP was devoid of oestrogenic activity in vitro (Lee et al. 2012).
Guidance for Industry - Food and Drug Administration
exposure to dibutyl phthalate (DBP) and di(2-ethylhexyl) phthalate (DEHP). In particular, the guidance recommends that you, as part of the pharmaceutical industry, avoid the use of these two
Fe-Activated Peroxymonosulfate Enhances the Degradation
Soil contamination by organic compounds has received worldwide concern for decades. Here, we found that dibutyl phthalate (DBP) could be degraded on moist quartz sand (QS, crystal, a typical soil constituent) during stirring, and the removal rate reached 57.2 ± 3.1% after 8 h of reaction. The introduction of peroxymonosulfate (PMS) and zerovalent iron (Fe0) substantially improved the
Full article: Detection of dibutyl phthalate in food samples
Because phthalate plasticisers cause great harm to the human body, they are prohibited from use in any food, medicine or health care products. As one of the common phthalate plasticiser, a method is urgently needed to detect the content of dibutyl phthalate (DBP) in food samples.
Hazards of diisobutyl phthalate (DIBP) exposure: A
Background: Biomonitoring studies indicate a trend towards increased human exposure to diisobutyl phthalate (DIBP), a replacement for dibutyl phthalate (DBP). Recent reviews have found DIBP to be a male reproductive toxicant, but have not evaluated other hazards of DIBP exposure.
- What is dibutyl phthalate (DBP)?
- Dibutyl phthalate (DBP) is an organic compound which is commonly used as a plasticizer in flexible plastics that are found in a variety of consumer products. The product is classified and labeled according to the Globally Harmonized System (GHS). GJ Chemical offers Dibutyl Phthalate (DBP), CAS# 84-74-2.
- How is dibutyl phthalate classified & labeled?
- The product is classified and labeled according to the Globally Harmonized System (GHS). GJ Chemical offers Dibutyl Phthalate (DBP), CAS# 84-74-2. Available in various grades, packaging and quantities from LTL to Bulk.
- Is dibutyl phthalate safe?
- A safety assessment of Dibutyl Phthalate (DBP), Diethyl Phthalate (DEP), and Dimethyl Phthalate (DMP)was published in 1985 with the conclusion that these ingredients “are safe for topical application in thepresent practices of use and concentrations in cosmetics” (Elder, 1985).
- What is Diisobutyl phthalate?
- 1.039 g/mL at 25 °C (lit.) n 20/D 1.49 (lit.) clear liquid Diisobutyl Phthalate is a Dialkyl phthalate ester phthalate plasticizer which can be used as a substitute of dibutyl phthalate. Diisobutyl Phthalate as well as other phthalates have genotoxic effects and studies shown an increase in its monoester metabolite in human urine over the years.
