Mechanisms of D1/D2-like dopaminergic agonist
Rotigotine ([-]2-(N-propyl-N-2-thienylethylamino)-5-hydroxytetraline) is a dopamine agonist with an affinity for all dopamine receptors (D1 to D5), which when delivered daily as a single dose
Ecopipam hydrobromide (SCH 39166 hydrobromide) | D1/D5
Ecopipam (SCH 39166) hydrobromide is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively. Ecopipam hydrobromide shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). Ecopipam hydrobromide can be used for the research of schizophrenia, cocaine addition, and
Dopamine D1/D5 Receptor Antagonists with Improved
Benzazepines 1 and 2 (SCH 23390 and SCH 39166, respectively) are two classical benzazepine D 1 /D 5 antagonists, with Ki values 1.4 and 1.2 nM, respectively. Compound 2 has been in human clinical trials for a variety of diseases, including schizophrenia, cocaine addition, and obesity.
Dopamine D1/D5 receptor antagonists with improved
Benzazepines 1 and 2 (SCH 23390 and SCH 39166, respectively) are two classical benzazepine D1/D5 antagonists, with Ki values 1.4 and 1.2 nM, respectively. Compound 2 has been in human clinical trials for a variety of diseases, including schizophrenia, cocaine addition, and obesity. Both 1 and 2 disp
The Dopamine D5 receptor contributes to activation
The D5 receptor belongs to the D1-type family of dopamine receptors that are coupled via Gα s /Gα olf and initiate cAMP/PKA signaling 10. Compared to the D1 receptor, in most regions...
