Toxicity review of diethyl phthalate (DEP) - U.S. Consumer
In general, DEP is manufactured commercially in a closed system by esterifying phthalic anhydride with ethanol using a concentrated sulfuric acid catalyst. As with other phthalates, the unreacted alcohols are recovered and reused, and the DEP mixture is purified by vacuum distillation or activated charcoal.
Guideline on the use of phthalates as excipients in human
on the impact of phthalate exposure are limited and therefore the clinical relevance of such findin gs remains to be established. The most commonly used phthalates in medicinal products licensed in the EU are: dibutyl phthalate (DBP), diethyl phthalate (DEP), polyvinyl acetate phthalate (PVAP), cellulose
SAFETY DATA SHEET - Fisher Sci
Diethyl phthalate Revision Date 24-Dec-2025 Viscosity No information available Molecular Formula C12 H14 O4 Molecular Weight 222.24 10. Stability and reactivity Reactive Hazard None known, based on information available Stability Stable under normal conditions. Conditions to Avoid Incompatible products.
Hazards of diethyl phthalate (DEP) exposure: A systematic
Diethyl phthalate (DEP), a colorless, odorless oily substance, is used to improve the performance and durability of many products ( Consumer Product Safety Commission, 2011, World Health Organization, 2003). As a plasticizer, it is added to plastic polymers to help maintain flexibility.
Biomonitoring Summary | CDC
Diethyl Phthalate. CAS No. 84-66-2. General Information. Diethyl phthalate (DEP) is a solvent used in many consumer products, particularly those containing fragrances. Products that may contain DEP include perfumes, colognes, deodorants, soaps, shampoos, and hand lotions. People exposed to DEP eliminate mono-ethyl phthalate (MEP) in their urine.
- What is diethyl phthalate?
- Diethyl phthalate (DEP) is a member of the group of esters of phthalic acid known as phthalates, used ubiquitously as solvents and plasticisers worldwide. DEP can increases the flexibility of plastics. It is also contained in deodorant formulations, perfumes, emollients and insect repellents. It can cross react with dimethyl phtalate.
- Is diethyl phthalate soluble in water?
- Diethyl Phthalate (DEP) is a commonly used chemical compound, primarily known for its use as a plasticizer. It is a colorless, odorless liquid that is soluble in various organic solvents but only slightly soluble in water. DEP is produced by the esterification of phthalic anhydride with ethanol.
- What is a diethyl phthalate (DEP) hazard assessment?
- www.nicnas.gov.auOverviewThis review of diethyl phthalate (DEP) is a he lth hazard assessment only. For this assessment, the International Programme on Chemical Safety: Concise International Chemical Assessment Document and Opinion of the Scientific Committee on Cosmetic and Non-Food Products intended for cons
- What does diethyl phthalate taste like?
- Diethyl phthalate is produced in the reaction of phthalic anhydride with ethanol in the presence of concentrated sulphuric acid catalyst. Clear, colorless, oily liquid with a mild, chemical odor. Bitter taste. Virtually odorless when pure ("Perfumery grade" of commercial Diethyl phthalate). Very bitter taste in weak hydro-alcoholic solution.
- Is diethyl phthalate toxic?
- [Handling Chemicals Safely 1980. p. 250]. Diethyl phthalate exhibited low to very lowacute toxicity in laboratory animals. Inges tion produced somnolence and hypotension.Inhalation of its vapors may result in lacrima tion, coughing, and irritation of the throatin humans. The oral LD50 value in mice is6170 mg/kg.
- Can diethyl phthalate cross react with dimethyl phtalate?
- It is also contained in deodorant formulations, perfumes, emollients and insect repellents. It can cross react with dimethyl phtalate. Diethyl phthalate is a clear, colorless, oily liquid. It is practically odorless, or with a very slight aromatic odor and a bitter, disagreeable taste. It is miscible with ethanol and ethyl ether.
