Hazards of diethyl phthalate (DEP) exposure: A systematic
Background. Diethyl phthalate (DEP) is widely used in many commercially available products including plastics and personal care products. DEP has generally not been found to share the antiandrogenic mode of action that is common among other types of phthalates, but there is emerging evidence that DEP may be associated with other types of health effects.
Guideline on the use of phthalates as excipients in human
on the impact of phthalate exposure are limited and therefore the clinical relevance of such findin gs remains to be established. The most commonly used phthalates in medicinal products licensed in the EU are: dibutyl phthalate (DBP), diethyl phthalate (DEP), polyvinyl acetate phthalate (PVAP), cellulose
Toxicity review of diethyl phthalate (DEP) - U.S. Consumer
TOXICITY REVIEW FOR DIETHYL PHTHALATE (DEP) Contract No. CPSC-D-06-0006 Task Order 012 Prepared by: Versar Inc. 6850 Versar Center Springfield, VA 22151 and SRC, Inc. 7502 Round Pond Road North Syracuse, NY 13212 Prepared for: Kent R. Carlson, Ph.D. U.S. Consumer Product Safety Commission 4330 East West Highway Bethesda, MD 20814
Biomonitoring Summary | CDC
Diethyl Phthalate. CAS No. 84-66-2. General Information. Diethyl phthalate (DEP) is a solvent used in many consumer products, particularly those containing fragrances. Products that may contain DEP include perfumes, colognes, deodorants, soaps, shampoos, and hand lotions. People exposed to DEP eliminate mono-ethyl phthalate (MEP) in their urine.
Diethyl phthalate
Diethyl phthalate ( DEP) is a phthalate ester. It occurs as a colourless liquid without significant odour but has a bitter, disagreeable taste. It is more dense than water and insoluble in water; hence, it sinks in water. Synthesis and applications [ edit]
- What is diethyl phthalate (DEP)?
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- ) Diethyl phthalate (DEP) is a phthalate ester. It is a colourless liquid without significant odour but with a bitter disagreeable taste. Diethyl phthalate is produced by the reaction of ethanol with phthalic anhydride, in the presence of a strong acid catalyst:
- Is diethyl phthalate soluble in water?
- Diethyl Phthalate (DEP) is a commonly used chemical compound, primarily known for its use as a plasticizer. It is a colorless, odorless liquid that is soluble in various organic solvents but only slightly soluble in water. DEP is produced by the esterification of phthalic anhydride with ethanol.
- What does diethyl phthalate taste like?
- Diethyl phthalate is produced in the reaction of phthalic anhydride with ethanol in the presence of concentrated sulphuric acid catalyst. Clear, colorless, oily liquid with a mild, chemical odor. Bitter taste. Virtually odorless when pure ("Perfumery grade" of commercial Diethyl phthalate). Very bitter taste in weak hydro-alcoholic solution.
- Is diethyl phthalate toxic?
- [Handling Chemicals Safely 1980. p. 250]. Diethyl phthalate exhibited low to very lowacute toxicity in laboratory animals. Inges tion produced somnolence and hypotension.Inhalation of its vapors may result in lacrima tion, coughing, and irritation of the throatin humans. The oral LD50 value in mice is6170 mg/kg.
- How is diethyl phthalate produced?
- Diethyl phthalate is produced by the reaction of phthalic anhydride with ethanol in the presence of sulfuric acid. ChEBI: The diethyl ester of benzene-1,2-dicarboxylic acid. Tetrahedron Letters, 34, p. 2629, 1993 DOI: 10.1016/S0040-4039 (00)77642-8
- Can diethyl phthalate cross react with dimethyl phtalate?
- It is also contained in deodorant formulations, perfumes, emollients and insect repellents. It can cross react with dimethyl phtalate. Diethyl phthalate is a clear, colorless, oily liquid. It is practically odorless, or with a very slight aromatic odor and a bitter, disagreeable taste. It is miscible with ethanol and ethyl ether.
