Formulation and characterization of fast dissolving oral films
Selection of film formers and plasticizer Various combinations of film-forming agents (PVA, HPMC E15, Maltodextrin, Sodium Alginate, HPMC E15 and PVA in 1:1 ratio) and plasticizers (PEG 400 and propylene glycol) were studied for their film-forming and plasticizing properties.
Plasticizers for Softgel Capsules - SPI Pharma
Effect on finished product's physical and chemical stability Sorbitol Special Softgel Plasticizers Sorbitol Special plasticizers are the original sorbitol-based softgel plasticizers. Their superior plasticizing effect results in shorter capsule drying time and inhibited blooming.
A REVIEW REPORT ON: COATING OF SOFT GELATIN CAPSULES
Influence of Plasticizer & Fill Liquid on Polymer Adhesion Good adhesion between a polymer and the surface of a solid is a major prerequisite for the film coating of pharmaceutical dosage forms. Loss of adhesion may lead to an accumulation of moisture at the film-capsule interface, significantly affecting the stability of drugs susceptible to degradation by hydrolytic mechanisms.
Soft Gelatin Capsules (Softgel): Formulation and Manufacturing
Soft gelatin capsules, also known as softgels or soft elastic capsules, are hermetically sealed one-piece capsules containing a liquid or a semisolid fill without a bubble of air or gas. They are made from a more flexible, gelatin film plasticized by the addition of glycerine, sorbitol, or a similar polyol. As with hard gelatin capsules, soft
SoftGel Capsules | Gelatin Capsule | SoftGels Dosage Form
Plasticizers are used mainly for oral solid dosage forms to facilitate oral pharmaceutical applications. Plasticizers are added to polymers used as film forming agents in order to make them pliable and soft, thereby enhancing the flexibility and plasticity of the films.
- What is sorbitol special plasticizer?
- Effect on finished product's physical and chemical stability Sorbitol Special plasticizers are the original sorbitol-based softgel plasticizers. Their superior plasticizing effect results in shorter capsule drying time and inhibited blooming.
- Which compounds are used in plasticizers for sunflower protein isolate films?
- The use of five compounds (GLY, EG, DEG, TEG and PG) as plasticizers for sunflower protein isolate films, producing soft, brown and smooth films, with good mechanical properties and a high level of impermeability to water vapor .
- Which plasticizer is best for gelatin films?
- In terms of functional properties, GLY presented higher plasticizing effect and efficiency. Other plasticizers such as sucrose, oleic acid, citric acid, tartaric acid, malic acid, PEG, sorbitol, mannitol, EG, DEG, TEG, EA, diethanolamine (DEA) and TEA were also applied for gelatin films, modifying their mechanical and barrier properties.
- Why are plasticizers important in film forming?
- Plasticizers are a very important component of the film-forming formulation. They are to be added in a minute amount in the formulation to provide the necessary flexibility to the film and to enhance the water permeation through the film.31Some plasticizers also act as drug diffusion enhancers along with providing plasticity to the film.
- Which polymers can be used to prepare film-forming formulations?
- Both natural and synthetic polymers can be useg to prepare the film-forming formulations. There is wide variety of options of the film-forming formulations like solvent, gel and emulsions too. Metered-dose sprays give more accurate dose with more ease for application. Patient compliance is expected to increase with the help of this concept.
- What are biodegradable plasticizers?
- Biodegradable plasticizers such as soybean oil (SO), epoxidized soybean oil (ESO), dibutyl phthalate (DBP) and triethyl citrate (TEC) were added to poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) films, enhancing their thermal and mechanical properties. TEC or DBP presented better plasticizing effects than SO and ESO for PHBV .
