Plasticizer Interaction With the Heart: Chemicals Used
Heightened clinical exposure to plasticized medical products may have cardiac safety implications-given that action potential triangulation and electrical restitution modifications are a risk factor for early after depolarizations and cardiac arrhythmias. Keywords: action potentials; electrophysiology; heart; plasticizer; plastics.
Plastics and cardiovascular disease | Nature Reviews Cardiology
Jaimes, R. et al. Plasticizer interaction with the heart: chemicals used in plastic medical devices can interfere with cardiac electrophysiology. Circ. Arrhythmia Electrophysiol. 12, e007294...
Plasticizer Interaction With the Heart | Circulation
Indeed, animal studies have shown a causal relationship between phthalate exposure and subsequent alterations in cardiovascular function. 35–39 Using a rodent heart-lung preparation, Labow, et al 38 showed that phthalates exert a hypertensive effect on the pulmonary vasculature.
Plasticizer interaction with the heart - Medical Xpress
More information: Rafael Jaimes et al, Plasticizer Interaction With the Heart, Circulation: Arrhythmia and Electrophysiology (2025). DOI: 10.1161/CIRCEP.119.007294 Provided by Children's National
Plasticizer interaction with the heart | Children's National
Plasticizer interaction with the heart July 24, 2025 Calling an ambulance during an emergency, emailing a journal article before a 5 p.m. deadline and maintaining conditions during the fifth week of a 6-week lab study, without altering the light or temperature, requires electricity and translates into time, money and lives saved.
- Are plasticizers a risk factor for cardiac arrhythmias?
- Heightened clinical exposure to plasticized medical products may have cardiac safety implications-given that action potential triangulation and electrical restitution modificationsare a risk factor for early after depolarizations and cardiac arrhythmias. Keywords: action potentials; electrophysiology; heart; plasticizer; plastics.
- Can plasticizers interfere with cardiac electrophysiology?
- Jaimes, R. et al. Plasticizer interaction with the heart: chemicals used in plastic medical devices can interfere with cardiac electrophysiology. Circ. Arrhythmia Electrophysiol. 12, e007294 (2019). The author is supported by the NIH (R01HL139472) and the Children’s Heart Institute.
- Are phthalates a plasticizer?
- Background:Phthalates are used as plasticizers in the manufacturing of flexible, plastic medical products. Patients can be subjected to high phthalate exposure through contact with plastic medical devices.
- Are plastics a risk factor for cardiovascular disease?
- Nature Reviews Cardiology 18 , 69–70 ( 2021) Cite this article Plastics are synonymous with modern life. Nevertheless, the ubiquity of plastics has resulted in their continuous exposure to humans, which can be harmful. The available literature suggests that this daily exposure might be contributing to cardiovascular disease.
- Are Plasticizer additives harmful to humans?
- Plastics are indispensable materials; however, their ubiquity has raised concerns about the continuous exposure of humans to plastics. To date, these concerns are primarily directed towards plasticizer additives, such as di (2-ethylhexyl) phthalate (DEHP) and synthetic chemicals used to create polymers, such as bisphenol A (BPA).
- How does BPA affect the heart?
- For example, BPA exposure disrupts myocardial calcium signalling, which is an important regulator of electrical activity, contractile function and vasoactivity. Acute exposure to BPA inhibits voltage-gated calcium channels and impairs intracellular calcium dynamics in rodent cardiomyocytes and ex vivo rodent heart tissue.
