Differentiation of DOTP and DNOP in analysis of restricted

                                               
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  • Is DOTP a terephthalate plasticizer?
  • D.O.T.P is a terephthalate plasticizer and has a very different structure in structure as seen from its open formulas from orthoftalate esters such as D.O.P, D.I.O.P, D.I.N.P, D.I.D.P. This branched structure of D.O.T.P provides D.O.T.P many excellent features not found in other plasticizers.
  • Why is DOTP branched?
  • This branched structure of D.O.T.P provides D.O.T.P many excellent features not found in other plasticizers. The volatility of plastisols (mixture of P.V.C and plasticizer) during the fusion process is determined by weight loss at various fusion temperatures.
  • What is the difference between DEHP and DNOP?
  • DEHP is classified for reproductive and developmental effects while DnOP is not, even though they both are made with alcohols containing 8 carbons; the difference is the C6 versus C8 backbone.
  • Are physiological based pharmacokinetic models available for DOTP?
  • Recently, physiological based pharmacokinetic models (PBPK) were published for DINCH (McNally et al., 2019) and for two ortho-phthalates, DINP (Campbell et al., 2020) and di-propyheptyl phthalate (DPHP, McNally et al., 2021). We understand that a model for DOTP also is under development.
  • What is the migration of DOTP and DINCH into olive oil?
  • The migration of DOTP into olive oil was 60 mg/kg; the migration of DINCH into sunflower oil was 174 mg/kg. In some cases, with higher fat foods, migration of these two plasticizers may exceed the SML; however, potential human exposures depend on more than just the migration into food simulants.
  • Is DBT approved under FCN 744?
  • DBT is approved under FCN No 744 in adhesives that comply with 21 CFR 175.105, in pressure sensitive adhesives that comply with 21 CFR 175.125, and as a coating or component of paper or paperboard intended for use in contact with dry foods with no free surface fat or oil in compliance with 21 CFR 176.180.