Phthalate and alternative plasticizers in indwelling medical
The pattern of contamination observed for DEHP/ DEHA/ DEHT could be explained by the use of raw materials (plasticizers) of low purity. The amounts of impurities depend on the nature and the purity of the raw plasticizer used [22, 23]. When considering samples with one main plasticizer, the popularity of DEHT becomes more pronounced, as it was
What is DEHP? Where is it used? Why is it used? | U.S. Plastic
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What is the best alternative to DEHP for medical-grade PVC
Purity. If processed in truly dedicated equipment, DOTP can be produced nearly free of DEHP contamination. DOTP plasticizer producers specify a DEHP content of less than 50 parts per million, but almost all shipments contain significantly less than that. By contrast, TOTM can contain as much as 2,000 ppm of DEHP and is never free of it.
Non-phthalate plasticizer DEHT preserves adequate blood
Materials and methods: RBC concentrates (N = 64), platelet concentrates (N = 16) and fresh frozen plasma (N = 32) were produced from whole blood collected into either DEHT or DEHP plasticized systems. Using a pool-and-split study design, pairs of identical RBC content were created within each plasticizer arm and assigned either SAGM or PAGGSM.
DEHT is a suitable plasticizer option for phthalate-free
Abstract. Background and objectives: Due to increasing concerns about possible endocrine-disrupting properties, the use of the plasticizer di (2-ethylhexyl) phthalate (DEHP) will be banned in future blood storage. Di (2-ethylhexyl) terephthalate (DEHT) provides sufficient red blood cell (RBC) quality during conventional blood bank storage.
- Why is DEHP used in plasticization and processing of PVC?
- The excellent performance of DEHP in the plasticization and processing of PVC explains its wide use in medical devices over the past few years. The strategy was to adjust the chemical nature of the lateral alkyl chains in order to reduce the leaching of the plasticizers into the surrounding medium.
- Which plasticizers are used in MDS?
- The review focuses on the aternative to DEHP plasticizers currently used in the MDs. Their migration from PVC depends partially on their physicochemical properties. The patient׳s exposure is the main risk and has to be investigated. Appropriate analytical methods are developed to quantify them in different matrices.
- Are there alternatives to DEHP?
- MD manufacturers were therefore forced to quickly find alternatives to DEHP to maintain the elasticity of PVC nutrition tubings, infusion sets and hemodialysis lines. Several replacement plasticizers, so-called “alternative to DEHP plasticizers” were incorporated into the MDs.
- What is diethylhexylphthalate (DEHP)?
- Until 2010, diethylhexylphthalate (DEHP) was the plasticizer most commonly used to soften PVC medical devices (MDs), because of a good efficiency/cost ratio. In flexible plasticized PVC, phthalates are not chemically bound to PVC and they are released into the environment and thus may come into contact with patients.
- Is DEHP a toxicity hazard?
- The European Directive 2007/47/CE, classified DEHP as a product with a toxicity risk and restricted its use in MDs. MD manufacturers were therefore forced to quickly find alternatives to DEHP to maintain the elasticity of PVC nutrition tubings, infusion sets and hemodialysis lines.
- What is the abbreviation for DEHP?
- Abbreviations: DEHP (Di (2-ethylhexyl)phthalate), TOTM (Tri-octyltrimellitate), DEHA (Di- (2-ethylhexyl) adipate), ATBC (acetyltri-n-butyl citrate), DEHT (di- (2-ethylhexyl) terephthalate), DINP (Di- (isononyl) phthalate), DINCH (Di (isononyl)-cyclohexane-1,2-dicarboxilic acid) PVC at 50 phr plasticizer.
