Bis(2-ethylhexyl) phthalate
DEHP is the most common phthalate plasticizer in medical devices such as intravenous tubing and bags, IV catheters, nasogastric tubes, dialysis bags and tubing, blood bags and transfusion tubing, and air tubes. DEHP makes these plastics softer and more flexible and was first introduced in the 1940s in blood bags.
A potentially general approach to aliphatic ester-derived PVC
The safety of flexible polyvinyl chloride (PVC) materials is now being questioned, partially due to allegations that di-(2-ethylhexyl) phthalate (DEHP), the dominant PVC plasticizer, is an endocrine disruptor and a probable carcinogen. As sustainable alternatives, aliphatic ester-derived plasticizers feature
Non-phthalate plasticizer DEHT preserves adequate blood
Materials and methods: RBC concentrates (N = 64), platelet concentrates (N = 16) and fresh frozen plasma (N = 32) were produced from whole blood collected into either DEHT or DEHP plasticized systems. Using a pool-and-split study design, pairs of identical RBC content were created within each plasticizer arm and assigned either SAGM or PAGGSM.
DEHT is a suitable plasticizer option for phthalate-free
Abstract Background and objectives: Due to increasing concerns about possible endocrine-disrupting properties, the use of the plasticizer di (2-ethylhexyl) phthalate (DEHP) will be banned in future blood storage. Di (2-ethylhexyl) terephthalate (DEHT) provides sufficient red blood cell (RBC) quality during conventional blood bank storage.
What is the best alternative to DEHP for medical-grade PVC
Purity. If processed in truly dedicated equipment, DOTP can be produced nearly free of DEHP contamination. DOTP plasticizer producers specify a DEHP content of less than 50 parts per million, but almost all shipments contain significantly less than that. By contrast, TOTM can contain as much as 2,000 ppm of DEHP and is never free of it.
- What is DEHP used for?
- Due to its suitable properties and the low cost, DEHP is widely used as a plasticizer in manufacturing of articles made of PVC. Plastics may contain 1% to 40% of DEHP. It is also used as a hydraulic fluid and as a dielectric fluid in capacitors. DEHP also finds use as a solvent in glowsticks.
- Which phthalate plasticizer is used in medical devices?
- DEHP is the most common phthalate plasticizer in medical devices such as intravenous tubing and bags, IV catheters, nasogastric tubes, dialysis bags and tubing, blood bags and transfusion tubing, and air tubes. DEHP makes these plastics softer and more flexible and was first introduced in the 1940s in blood bags.
- How much DEHP is in plastic?
- Plastics may contain 1% to 40% of DEHP. It is also used as a hydraulic fluid and as a dielectric fluid in capacitors. DEHP also finds use as a solvent in glowsticks. Approximately three million tonnes are produced and used annually worldwide.
- Is DEHP a reprotoxin?
- DEHP has now been classified as a Category 1B reprotoxin, and is now on the Annex XIV of the European Union's REACH legislation. DEHP has been phased out in Europe under REACH and can only be used in specific cases if an authorization has been granted.
- Is DEHP a cancer hazard?
- DEHP is classified as a "chemical known to the State of California to cause cancer and birth defects or other reproductive harm" (in this case, both) under the terms of Proposition 65.
- Are there alternative plasticizers for flexible PVC articles?
- Manufacturers of flexible PVC articles can choose among several alternative plasticizers offering similar technical properties as DEHP.
