A potentially general approach to aliphatic ester-derived PVC
The safety of flexible polyvinyl chloride (PVC) materials is now being questioned, partially due to allegations that di-(2-ethylhexyl) phthalate (DEHP), the dominant PVC plasticizer, is an endocrine disruptor and a probable carcinogen. As sustainable alternatives, aliphatic ester-derived plasticizers feature
Analytical methods for the determination of DEHP plasticizer
It was also successfully used by Rothenbacher et al. [50] to determine if a rapid screening test for plasticizers (like DEHP, DINP, or DINCH) in PVC materials can be developed using direct analysis in real time mass spectrometry (DART-MS). An open interface would allow the direct insertion of solid specimens, such as samples of medical devices.
Plasticizer for poly(vinyl chloride) from cardanol as a
High purity, small scale esterification was performed in order to study the plasticizing effectiveness of the derived plasticizer, but let us produce no more than 7.5 g of plasticizer. This high purity esterification was obtained using, 7 g of cardanol and 6.57 ml (7.09 mol, 3 equivalents) of acetic anhydride, diluted in 5 ml di pyridine, and
Widespread Plasticizer Clouds Doping Tests of Cyclists
The World Anti-Doping Agency funded research to develop a plasticizer test that would catch cheating cyclists, but so far it's not the smoking gun that many have hoped for. Plasticizers known...
Patients’ exposure to PVC plasticizers from ECMO circuits
Results: Trioctyltrimellitate (TOTM), main plasticizer present in circuit (44% w/w), is weakly released during ECMO. Concentrations are not cytotoxic and exposure doses are lower than DNEL. In...
- Why is DEHP used in plasticization and processing of PVC?
- The excellent performance of DEHP in the plasticization and processing of PVC explains its wide use in medical devices over the past few years. The strategy was to adjust the chemical nature of the lateral alkyl chains in order to reduce the leaching of the plasticizers into the surrounding medium.
- Can NMR detect traces of DEHP in PVC medical devices?
- Genay et al. used NMR to identify traces of DEHP in PVC medical devices presented as DEHP-free, i.e., with an amount lower than 0.1% . However, Lutyten et al. identified several drawbacks, including low sensitivity, while working on the quantification of different plasticizers present in PVC tubes.
- How much DEHP is in plastic?
- Plastics may contain 1% to 40% of DEHP. It is also used as a hydraulic fluid and as a dielectric fluid in capacitors. DEHP also finds use as a solvent in glowsticks. Approximately three million tonnes are produced and used annually worldwide.
- Does PVC contain DEHP?
- PVC formulations can contain DEHP in concentrations ranging from 1 % to 40 %. The migration of DEHP is a critical issue due to its toxicity, particularly in the pharmaceutical industry, in medicine and in food packaging [9, 11].
- Is DEHP leachable from PVC-blood bags?
- The optimized method was applied to evaluate the leachability of DEHP or DINCH from PVC-blood bags and to determine the concentration of their corresponding metabolite MEHP and MINCH in the four LBP. Blank sample was performed every five analyses in order to verify that no carryover occurred.
- What is DEHP used for?
- Due to its suitable properties and the low cost, DEHP is widely used as a plasticizer in manufacturing of articles made of PVC. Plastics may contain 1% to 40% of DEHP. It is also used as a hydraulic fluid and as a dielectric fluid in capacitors. DEHP also finds use as a solvent in glowsticks.
