TEC Plasticization of Topical Polymeric Films | SpringerLink
The degree of homogeneity and the mechanical properties of topical polymeric films for drug delivery are vital to their efficacy. The dispersal of plasticizer and the solubility of the drug within the films (the homogeneity of their distribution) affect their function; phase separations have been shown to trigger drug crystallization [] and the efficacy (bioavailability) and stability of the
Topical Polymeric Films and Transdermal Patches | BASF Pharma
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Formulation considerations in the design of topical, polymeric film
Abstract Polymeric film-forming systems (FFSs) are potential drug delivery systems for topical application to the skin. The FFSs form thin and transparent polymeric films in situ upon solvent evaporation. Their application convenience and cosmetic attributes, superior to conventional semi-solids, may offer improved patient compliance.
Blended polymeric films containing the drugs simvastatin and
In this study, blended films of simvastatin (SIM) and resveratrol (RESV) were developed to improve the release of both poorly soluble drugs, aiming for the topical treatment of melanoma. RESV films containing different plasticizer content (polysorbate 80) exhibited residual crystals in the polymeric matrix of EudragitRL.
Lipid Incorporation into Topical Polymeric Films | SpringerLink
As discussed in the previous chapter, triethyl citrate (TEC) is one of several compounds, which are commonly used to plasticize polymeric films (others include dibutyl sebacate and tributyl citrate [1, 2]). The type of plasticizer incorporated into the films has been shown affect drug release [3–5].
- What is a polymeric film forming system?
- Polymeric film-forming systems (FFSs) are potential drug delivery systems for topical application to the skin. The FFSs form thin and transparent polymeric films in situ upon solvent evaporation. Their application convenience and cosmetic attributes, superior to conventional semi-solids, may offer improved patient compliance.
- Which plasticizers are used to improve film characteristics?
- Although films were obtained and their characteristics were acceptable, most of them were difficult to peel off from the skin because of their lack of flexibility and dryness. Therefore, different plasticizers (PPG, MCT, TEC, and PEG-300) were used to improve the film characteristics.
- What is a topical film forming system?
- Topical film forming systems are such developing drug delivery systems meant for topical application to the skin, which adhere to the body, forming a thin transparent film and provide delivery of the active ingredients to the body tissue.
- Why are plasticizers important in biopolymer-based films & coatings production?
- In biopolymer-based films and coatings production, plasticizers are also essential additives since they can improve flexibility and handling of films, maintain integrity and avoid pores and cracks in the polymeric matrix .
- Why are plasticizers used in film forming systems?
- Plasticizers Plasticizers are used in the film forming systems to impart flexibility to the film and improve the tensile strength of the film formed. The plasticizer used should be compatible with the polymers used and should have low skin permeability.
- Are polymeric film-forming systems a viable alternative to steroidal analgesics?
- Such an outcome will presumably rely on the composition of the formulation. While polymeric film-forming systems (FFSs) have been used for the transdermal delivery of steroidal hormones and analgesics for systemic therapeutic effect , , , , , , , they also represent attractive, alternative topical formulations in dermatology.
