Plasticizer Interaction With the Heart | Circulation: Arrhythmia and
Di-2-ethylhexyl phthalate (DEHP) is the most commonly used plasticizer in Food and Drug Association–approved medical devices, including blood storage bags, tubing circuits, enteral feeding tubes, endotracheal tubes, and catheters. 4 In the finished product, DEHP can contribute up to 40% by weight in intravenous bags and 80% by weight in medical
Plasticizer Interaction With the Heart: Chemicals Used in Plastic
Heightened clinical exposure to plasticized medical products may have cardiac safety implications-given that action potential triangulation and electrical restitution modifications are a risk factor for early after depolarizations and cardiac arrhythmias. Keywords: action potentials; electrophysiology; heart; plasticizer; plastics.
Abstract 454: Plasticizer Interaction With the Heart: Chemicals Used
Abstract 454: Plasticizer Interaction With the Heart: Chemicals Used in Plastic Medical Devices Can Interfere With Cardiac Electrophysiology | Circulation Research Background: Phthalates are employed as plasticizers in the manufacturing of flexible, plastic medical products.
[PDF] Plasticizer Interaction With the Heart | Semantic Scholar
This review aims to provide an updated understanding of environmental influences on cardiovascular aging, by summarizing epidemiological and mechanistic evidence for the cardiovascular health impact of major environmental stressors, including air pollution, endocrine-disrupting chemicals, metals, and climate change. Expand 2 Save Alert ... 1 2
Plasticizer Interaction With the Heart: Chemicals Used in Plastic
Heightened clinical exposure to plasticized medical products may have cardiac safety implications—given that action potential triangulation and electrical restitution modifications are a risk factor for early after depolarizations and cardiac arrhythmias. Keywords: action potentials, electrophysiology, heart, plasticizer, plastics WHAT IS KNOWN?
- Are plasticizers a risk factor for cardiac arrhythmias?
- Heightened clinical exposure to plasticized medical products may have cardiac safety implications-given that action potential triangulation and electrical restitution modificationsare a risk factor for early after depolarizations and cardiac arrhythmias. Keywords: action potentials; electrophysiology; heart; plasticizer; plastics.
- Can plasticizers interfere with cardiac electrophysiology?
- Jaimes, R. et al. Plasticizer interaction with the heart: chemicals used in plastic medical devices can interfere with cardiac electrophysiology. Circ. Arrhythmia Electrophysiol. 12, e007294 (2019). The author is supported by the NIH (R01HL139472) and the Children’s Heart Institute.
- Are phthalates a plasticizer?
- Background:Phthalates are used as plasticizers in the manufacturing of flexible, plastic medical products. Patients can be subjected to high phthalate exposure through contact with plastic medical devices.
- Does plastic cause heart disease?
- NYU Langone study linked exposure to phthalate chemicals found in plastic to more than 356,000 global deaths from heart disease in 2018 alone. Learn more.
- Are Plasticizer additives harmful to humans?
- Plastics are indispensable materials; however, their ubiquity has raised concerns about the continuous exposure of humans to plastics. To date, these concerns are primarily directed towards plasticizer additives, such as di (2-ethylhexyl) phthalate (DEHP) and synthetic chemicals used to create polymers, such as bisphenol A (BPA).
- How does phthalate affect heart function?
- Acute exposure to DEHP or its main metabolite, mono (2-ethylhexyl) phthalate, decreases coronary flow and systolic tension in rat intact heart preparations and decreases contractile function in atrial tissue preparations. Moreover, phthalate treatment slows heart rate, atrioventricular conduction and epicardial conduction velocity 10.
