TEC Plasticization of Topical Polymeric Films | SpringerLink
The degree of homogeneity and the mechanical properties of topical polymeric films for drug delivery are vital to their efficacy. The dispersal of plasticizer and the solubility of the drug within the films (the homogeneity of their distribution) affect their function; phase separations have been shown to trigger drug crystallization [] and the efficacy (bioavailability) and stability of the
Topical Polymeric Films and Transdermal Patches | BASF Pharma
Develop a broad range of topical polymeric films and transdermal patches with our diverse selection of film formers, matrix formers, plasticizers, and solvents. Explore Our Diverse Product Portfolio Kollicream Mild emollients aiding in the dermal penetration of active ingredients View products Kollisolv
Film-Forming Systems in Topically Administered
Polymeric films can be previously prepared or formed in situ, after application of a film-forming system (FFS) used as a drug dosage form or to protect a dosage form or as a drug dosage form...
Eastman Product List for Polymeric Plasticizers
Admex 525 is a low molecular weight, polymeric plasticizer. Admex 760 is an ultra-high molecular weight, polymeric adipate. It possesses maximum resistance to extraction, migration and volatility. Admex 770 is a medium molecular weight, polymeric adipate. It is characterized by a mild ester odor and very light color.
Film-Forming Systems in Topically Administered Pharmaceutical
In the context of topical formulations, polymeric film forming systems (FFS) created in situ after administration are a more efficient topical formulation alternative that can promote more patient compliance as it provides the required dose of drug and allows less frequent administration.
- What is a polymeric film forming system?
- Polymeric film-forming systems (FFSs) are potential drug delivery systems for topical application to the skin. The FFSs form thin and transparent polymeric films in situ upon solvent evaporation. Their application convenience and cosmetic attributes, superior to conventional semi-solids, may offer improved patient compliance.
- What is a topical film forming system?
- Topical film forming systems are such developing drug delivery systems meant for topical application to the skin, which adhere to the body, forming a thin transparent film and provide delivery of the active ingredients to the body tissue.
- Why are plasticizers used in film forming systems?
- Plasticizers Plasticizers are used in the film forming systems to impart flexibility to the film and improve the tensile strength of the film formed. The plasticizer used should be compatible with the polymers used and should have low skin permeability.
- Are polymeric film-forming systems a viable alternative to steroidal analgesics?
- Such an outcome will presumably rely on the composition of the formulation. While polymeric film-forming systems (FFSs) have been used for the transdermal delivery of steroidal hormones and analgesics for systemic therapeutic effect , , , , , , , they also represent attractive, alternative topical formulations in dermatology.
- Why are plasticizers important in biopolymer-based films & coatings production?
- In biopolymer-based films and coatings production, plasticizers are also essential additives since they can improve flexibility and handling of films, maintain integrity and avoid pores and cracks in the polymeric matrix .
- What are the benefits of topical polymeric films & transdermal patches?
- Due to their benefits such as physical barrier formation, ease of application, and reduced dosing frequency, topical polymeric films and transdermal patches are often associated with improved patient compliance.
