SKF-83566 | Dopamine D1/D5 Receptor Antagonist | MedChemExpress
SKF-83566 is a potent, blood-brain permeable and orally active D1-like dopamine receptor (D1DR) antagonist and a weaker competitive antagonist at the vascular 5-HT2 receptor (Ki=11 nM). SKF-83566 is a competitive DAT (dopamine transporter) inhibitor with an IC50 of 5.7 μM. SKF-83566 also shows selective inhibition for adenylyl cyclase 2 (AC2) over AC1 and AC5 in the isolated rabbit thoracic
Ecopipam hydrobromide (SCH 39166 hydrobromide) | D1/D5
Ecopipam (SCH 39166) hydrobromide is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively. Ecopipam hydrobromide shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). Ecopipam hydrobromide can be used for the research of schizophrenia, cocaine addition, and
Mechanisms of D1/D2-like dopaminergic agonist
Rotigotine ( [-]2- (N-propyl-N-2-thienylethylamino)-5-hydroxytetraline) is a dopamine agonist with an affinity for all dopamine receptors (D1 to D5), which when delivered daily as a...
D1 and D5 Receptor Antagonists - Tocris Bioscience
D 1 and D 5 Receptor Antagonists View all D 1 and D 5 Receptor products Related Targets D 2 Receptors D 3 Receptors D 4 Receptors Dopamine Transporters Monoamine Oxidases Distributor Information Your territory is served exclusively by our distributor network.
D5 receptor inhibitor | D5 receptor inhibition
D5 receptor, Ki: 9 nM: S5481: Molindone hydrochloride: Molindone hydrochloride is the hydrochloride salt form of molindone, a conventional antipsychotic used in the therapy of schizophrenia. It is a dopamine D2/D5 receptor antagonist. Pan: S7993: SKF38393 HCl: SKF38393 HCl is a selective dopamine D1/D5 receptor agonist. Pan
