Plasticizer Interaction With the Heart: Chemicals Used
Heightened clinical exposure to plasticized medical products may have cardiac safety implications-given that action potential triangulation and electrical restitution modifications are a risk factor for early after depolarizations and cardiac arrhythmias. Keywords: action potentials; electrophysiology; heart; plasticizer; plastics.
Plastics and cardiovascular disease | Nature Reviews Cardiology
high exposure to BPA was associated with a 46–49% higher hazard ratio for cardiovascular mortality and all-cause mortality These exposures are concerning because both DEHP and BPA have...
Plasticizer Interaction With the Heart | Circulation
Indeed, animal studies have shown a causal relationship between phthalate exposure and subsequent alterations in cardiovascular function. 35–39 Using a rodent heart-lung preparation, Labow, et al 38 showed that phthalates exert a hypertensive effect on the pulmonary vasculature.
Plasticizer Interaction With the Heart: Chemicals Used
Heightened clinical exposure to plasticized medical products may have cardiac safety implications—given that action potential triangulation and electrical restitution modifications are a risk factor for early after depolarizations and cardiac arrhythmias. Keywords: action potentials, electrophysiology, heart, plasticizer, plastics WHAT IS KNOWN?
[PDF] Plasticizer Interaction With the Heart | Semantic Scholar
This review aims to provide an updated understanding of environmental influences on cardiovascular aging, by summarizing epidemiological and mechanistic evidence for the cardiovascular health impact of major environmental stressors, including air pollution, endocrine-disrupting chemicals, metals, and climate change. Expand 2 Save Alert ... 1 2
- Can plasticizers interfere with cardiac electrophysiology?
- Jaimes, R. et al. Plasticizer interaction with the heart: chemicals used in plastic medical devices can interfere with cardiac electrophysiology. Circ. Arrhythmia Electrophysiol. 12, e007294 (2019). The author is supported by the NIH (R01HL139472) and the Children’s Heart Institute.
- Are plastics causing cardiovascular disease?
- Nevertheless, the ubiquity of plastics has resulted in their continuous exposure to humans, which can be harmful. The available literature suggests that this daily exposure might be contributing to cardiovascular disease. From water bottles to jumbo jets, plastics are one of the most widely used materials in the world.
- Are Plasticizer additives harmful to humans?
- Plastics are indispensable materials; however, their ubiquity has raised concerns about the continuous exposure of humans to plastics. To date, these concerns are primarily directed towards plasticizer additives, such as di (2-ethylhexyl) phthalate (DEHP) and synthetic chemicals used to create polymers, such as bisphenol A (BPA).
- How does phthalate affect heart function?
- Acute exposure to DEHP or its main metabolite, mono (2-ethylhexyl) phthalate, decreases coronary flow and systolic tension in rat intact heart preparations and decreases contractile function in atrial tissue preparations. Moreover, phthalate treatment slows heart rate, atrioventricular conduction and epicardial conduction velocity 10.
- Is phthalate a risk factor for heart disease?
- Moreover, epidemiological studies have reported associations between elevated urinary phthalate or bisphenol levels and an increased risk of coronary and peripheral artery disease, chronic inflammation, myocardial infarction, angina, suppressed heart rate variability and hypertension (reviewed previously 2 ).
- What happens if a plastic bag is exposed to DEHP?
- This effect unexpectedly acts as a preservative to stabilize red blood cells in DEHP-containing bags. Unfortunately, chemical leaching or migration can also result in substantial exposure of humans to DEHP through contact with these flexible plastics.
