Leaching of the plasticizer di(2-ethylhexyl)phthalate (DEHP
DEHP has come under increased scrutiny as its breakdown products are believed to be endocrine disruptors and more toxic than DEHP itself. DEHP and its breakdown products have been identified as ubiquitous environmental contaminants, and daily human exposure is estimated to be in the microgram per kilogram level.
Analytical methods for the determination of DEHP plasticizer
It was also successfully used by Rothenbacher et al. [50] to determine if a rapid screening test for plasticizers (like DEHP, DINP, or DINCH) in PVC materials can be developed using direct analysis in real time mass spectrometry (DART-MS). An open interface would allow the direct insertion of solid specimens, such as samples of medical devices.
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The Long Goodbye to DEHP-plasticized PVC | mddionline.com
The idea of scrapping the use of polyvinylchloride (PVC) materials containing di (2-ethylhexyl)phthalate (DEHP) plasticizers is not new. However, despite such endeavors, both PVC and DEHP plasticizer still abound in a variety of products, including garden hoses, building materials, toys, and such medical devices as, catheters, feeding tubes, and IV sets.
DEHT is a suitable plasticizer option for phthalate-free
Of the four combinations, membrane stability was least impacted in DEHP/PAGGSM. Conclusion: We demonstrate that DEHT is a suitable plasticizer for storage of RBCs after X-ray irradiation cell stress. This strengthens the option of DEHT as a viable non-phthalate substitute for DEHP.
- How much DEHP is in plastic?
- Plastics may contain 1% to 40% of DEHP. It is also used as a hydraulic fluid and as a dielectric fluid in capacitors. DEHP also finds use as a solvent in glowsticks. Approximately three million tonnes are produced and used annually worldwide.
- Why is DEHP used in plasticization and processing of PVC?
- The excellent performance of DEHP in the plasticization and processing of PVC explains its wide use in medical devices over the past few years. The strategy was to adjust the chemical nature of the lateral alkyl chains in order to reduce the leaching of the plasticizers into the surrounding medium.
- What is DEHP used for?
- Due to its suitable properties and the low cost, DEHP is widely used as a plasticizer in manufacturing of articles made of PVC. Plastics may contain 1% to 40% of DEHP. It is also used as a hydraulic fluid and as a dielectric fluid in capacitors. DEHP also finds use as a solvent in glowsticks.
- Which phthalate plasticizer is used in medical devices?
- DEHP is the most common phthalate plasticizer in medical devices such as intravenous tubing and bags, IV catheters, nasogastric tubes, dialysis bags and tubing, blood bags and transfusion tubing, and air tubes. DEHP makes these plastics softer and more flexible and was first introduced in the 1940s in blood bags.
- Are there alternatives to DEHP?
- MD manufacturers were therefore forced to quickly find alternatives to DEHP to maintain the elasticity of PVC nutrition tubings, infusion sets and hemodialysis lines. Several replacement plasticizers, so-called “alternative to DEHP plasticizers” were incorporated into the MDs.
- How to identify alternative plasticizers?
- It is easy to obtain general information using very simple non-separative methods suitable for identifying the alternative plasticizers. These methods rely on the general features of polymers, like PVC and their plasticizers, such as thermolability and spectral and electromagnetic characteristics.
