Exploiting Polymeric Films as a Multipurpose Drug Delivery
Polymeric films are drug delivery systems that maintain contact with the delivery tissue and sustain a controlled release of therapeutic molecules. These systems allow a longer time of drug contact with the target site in the case of topical treatments and allow the controlled administration of drugs. They can be manufactured by various methods such as solvent casting, hot melt extrusion
Topical Polymeric Films and Transdermal Patches | BASF Pharma
Develop a broad range of topical polymeric films and transdermal patches with our diverse selection of film formers, matrix formers, plasticizers, and solvents. Explore Our Diverse Product Portfolio Kollicream Mild emollients aiding in the dermal penetration of active ingredients View products Kollisolv
Specialty Plasticizers for Rubber/Elastomers | Hallstar
The elastomer requires antioxidants, anti-ozonants, fungicides, plasticizers, tackifiers and flame-retardants as the occasion and severity of the application demands. It can be cured with sulfur or peroxide systems. High ACN polymers require high polarity plasticizers, low ACN polymers require low polarity plasticizers.
TEC Plasticization of Topical Polymeric Films | SpringerLink
The degree of homogeneity and the mechanical properties of topical polymeric films for drug delivery are vital to their efficacy. The dispersal of plasticizer and the solubility of the drug within the films (the homogeneity of their distribution) affect their function; phase separations have been shown to trigger drug crystallization [] and the efficacy (bioavailability) and stability of the
Film-Forming Systems in Topically Administered Pharmaceutical
In the context of topical formulations, polymeric film forming systems (FFS) created in situ after administration are a more efficient topical formulation alternative that can promote more patient compliance as it provides the required dose of drug and allows less frequent administration.
- What is a topical film forming system?
- Topical film forming systems are such developing drug delivery systems meant for topical application to the skin, which adhere to the body, forming a thin transparent film and provide delivery of the active ingredients to the body tissue.
- Why are plasticizers used in film forming systems?
- Plasticizers Plasticizers are used in the film forming systems to impart flexibility to the film and improve the tensile strength of the film formed. The plasticizer used should be compatible with the polymers used and should have low skin permeability.
- Which polymers are plasticized?
- The plasticizers produced have been applied in 60 polymers and more than 30 groups of products. Industrially, the most common plasticized polymers are PVC, poly (vinyl butyral) (PVB), poly (vinyl acetate) (PVAc), acrylics, cellulose molding compounds, nylon, polyamides and certain copolyamides.
- What types of plasticizers are used in hydrophilic polymers?
- In addition to water, the most commonly used plasticizers are polyols, mono-, di- and oligosaccharides. Polyols have been found to be particularly effective for use in plasticized hydrophilic polymers .
- Why are plasticizers important in biopolymer-based films & coatings production?
- In biopolymer-based films and coatings production, plasticizers are also essential additives since they can improve flexibility and handling of films, maintain integrity and avoid pores and cracks in the polymeric matrix .
- How does a polymeric solution form a film?
- In this the polymeric solution is applied to the skin as a liquid or sprayed on the skin and forms an almost transparent film by solvent evaporation . The film forming sprays/solutions are made up of four main components – drug, solvent systems i.e. volatile and non-volatile vehicles, polymers and penetration enhancers.
