Novel ceramic processing method for substitution of toxic

                                               
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Selection of Solid-State Plasticizers as Processing Aids

                                               
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US Patent Application for Co-Plasticizer Systems Patent

                                               
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Bioplasticizer - an overview | ScienceDirect Topics

                                               
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WO2009085453A2 - Co-plasticizer systems - Google Patents

                                               
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  • What is a solid state plasticizer?
  • Based on comparable solubility parameters, stearic acid, glyceryl behenate, and polyethylene glycol 8000 were selected as solid-state plasticizers. Binary and ternary physical mixtures were evaluated as a function of plasticizer concentration for thermal and rheological behavior.
  • Are plasticizers effective as processing aids for HME process?
  • The physical and mechanical properties of plasticizers, in selected binary (polymer:plasticizer) and ternary (active pharmaceutical ingredient:polymer:plasticizer) systems, were evaluated to assess their effectiveness as processing aids for HME process.
  • Which solid-state plasticizers are used in a chemistry study?
  • Solubility parameters, thermal analysis, and rheological evaluation were used as assessment tools. Based on comparable solubility parameters, stearic acid, glyceryl behenate, and polyethylene glycol 8000 were selected as solid-state plasticizers.
  • How to select solid-state plasticizer?
  • The selection of solid-state plasticizer should include miscibility of plasticizer in polymer as well as API and its effect on T g and η 0 of the final system. It can be summarized that when components are miscible, different techniques will lead to the consistent plasticization effect prediction.
  • What plasticizers are used in hot-melt extruded systems?
  • Although commonly used pharmaceutical plasticizers such as triacetin, 4 citrate esters, 2, 5 and lower molecular weight polyethylene glycols 2, 3, 4 have been investigated in hot-melt extruded systems, almost all of them are liquid.
  • Do plasticizers affect HME process and product performance?
  • Although various studies have demonstrated the effect of plasticizers on HME process and product performance, 21, 22, 23, 24, 25 no single study has investigated the systematic approach for selecting a suitable plasticizer.