Leaching of the plasticizer di(2-ethylhexyl)phthalate (DEHP)
Di(2-ethylhexyl)phthalate (DEHP) is a widely used plasticizer to render poly(vinyl chloride) (PVC) soft and malleable. Plasticized PVC is used in hospital equipment, food wrapping, and numerous other commercial and industrial products.
Bis(2-ethylhexyl) phthalate
DEHP is the most common phthalate plasticizer in medical devices such as intravenous tubing and bags, IV catheters, nasogastric tubes, dialysis bags and tubing, blood bags and transfusion tubing, and air tubes. DEHP makes these plastics softer and more flexible and was first introduced in the 1940s in blood bags.
What is DEHP? Where is it used? Why is it used? | U.S. Plastic
Here is some information they have provided us about DEHP and its regulations. Di (2-Ethylhexyl) phthalate (DEHP) is a plasticizer used to make PVC soft and flexible. DEHP is the world's most widely used PVC plasticizer and is used in virtually every category of flexible PVC.
The Long Goodbye to DEHP-plasticized PVC | mddionline.com
The idea of scrapping the use of polyvinylchloride (PVC) materials containing di (2-ethylhexyl)phthalate (DEHP) plasticizers is not new. However, despite such endeavors, both PVC and DEHP plasticizer still abound in a variety of products, including garden hoses, building materials, toys, and such medical devices as, catheters, feeding tubes, and IV sets.
Effect of the Plasticizer DEHP in Blood Collection Bags on
Di-(2-ethylhexyl) phthalate (DEHP), a plasticizer known to be used in the manufacture of blood collection bags, was extracted from plasma obtained through three common techniques that allowed contact with DEHP, and drug fu values in plasma from each collection method were estimated using the HTDialysis protein binding methodology.
- Why is DEHP used in plasticization and processing of PVC?
- The excellent performance of DEHP in the plasticization and processing of PVC explains its wide use in medical devices over the past few years. The strategy was to adjust the chemical nature of the lateral alkyl chains in order to reduce the leaching of the plasticizers into the surrounding medium.
- Are medical devices containing DEHP Plasticized PVC safe?
- The safety of medical devices containing DEHP plasticized PVC or other plasticizers on neonates and other groups possibly at risk (2015 update). Regul. Toxicol.
- How to identify alternative plasticizers?
- It is easy to obtain general information using very simple non-separative methods suitable for identifying the alternative plasticizers. These methods rely on the general features of polymers, like PVC and their plasticizers, such as thermolability and spectral and electromagnetic characteristics.
- Do laboratory-produced PVC films have distinct patterns of DEHP release?
- A comprehensive evaluation of the laboratory-produced PVC films and commercially available PVC products revealed distinct patterns of DEHP release, thus emphasizing the role of exposure time, temperature, and solvent type in the migration process.
- What methods are used to detect plasticizers?
- According to the literature, gas and liquid chromatographic methods with MS detection are the most widely employed techniques. These methods are suitable for the detection and quantification of plasticizer amounts over a broad range of values, depending on the media and the plasticizer .
- Which plasticizers are used in MDS?
- The review focuses on the aternative to DEHP plasticizers currently used in the MDs. Their migration from PVC depends partially on their physicochemical properties. The patient׳s exposure is the main risk and has to be investigated. Appropriate analytical methods are developed to quantify them in different matrices.
