Bis(2-ethylhexyl) phthalate
Bis (2-ethylhexyl) phthalate ( di-2-ethylhexyl phthalate, diethylhexyl phthalate, diisooctyl phthalate, DEHP; incorrectly — dioctyl phthalate, DIOP) is an organic compound with the formula C 6 H 4 (CO 2 C 8 H 17) 2. DEHP is the most common member of the class of phthalates, which are used as plasticizers. It is the diester of phthalic acid
Analytical methods for the determination of DEHP plasticizer
Several replacement plasticizers, so-called “alternative to DEHP plasticizers” were incorporated into the MDs. Nowadays, the risk of exposure to these compounds for hospitalized patients, particularly in situations classified “at risk”, has not yet been evaluated, because migrations studies, providing sufficient exposure and human toxicity data have not been performed.
Leaching of the plasticizer di(2-ethylhexyl)phthalate (DEHP)
Exposure to DEHP also occurs in hospital environments, where DEHP leaches directly into liquids that passed through PVC/DEHP tubing and equipment. The latter exposure is at considerably higher levels compared to food and bottled water, specifically putting patients with chronic illnesses at risk.
THE SAFETY OF MEDICAL DEVICES CONTAINING DEHP-
animal and human studies. Also for DEHP a so called tolerable daily intake (TDI) was calculated in recent risk evaluations. Therefore an overview is presented on the safety of DEHP in medical devices. In addition, the availability, suitability and safety of alternative plasticizers for DEHP have been evaluated. Alternative materials for PVC
Plasticizers: Types, Uses, Classification, Selection & Regulation
Di-2-ethylhexyl-phthalate (DEHP, formula: C 6 H 4 (C 8 H 17 COO) 2) is a low molecular weight ortho-phthalate produced by esterification of phthalic anhydride with 2-ethyl-hexanol. It is non-volatile, colorless and odorless viscous liquid, soluble in oil, but not in water.
- Where is DEHP used?
- DEHP is the world's most widely used PVC plasticizer and is used in virtually every category of flexible PVC. Where is it used?
- and blood bags to footwear, electrical cables, packaging, and flooring. Why is it used?
- Plasticizers are essential to make PVC flexible.
- How much DEHP is in plastic?
- Plastics may contain 1% to 40% of DEHP. It is also used as a hydraulic fluid and as a dielectric fluid in capacitors. DEHP also finds use as a solvent in glowsticks. Approximately three million tonnes are produced and used annually worldwide.
- Why is DEHP used in PVC tubing?
- PVC is naturally rigid, but plasticizers are added to make the tubing flexible and expandable while retaining its shape. DEHP is widely used because it is low cost, processes well, and has provided good end-use performance. Why is Saint-Gobain Performance Plastics developing alternative tubing products that do not contain DEHP?
- Can DEHP be used in food contact products in Europe?
- DEHP cannot be used in food contact products, such as tubing, in Europe. This regulation is expected to impact North American food companies in the near future. Additionally, consumer and environmental advocacy groups have aggressively attacked the use of DEHP in the mainstream media.
- How to detect DEHP contamination and DEHP present in a sample?
- In order to discriminate DEHP contamination and DEHP present in the sample, a trap column was implemented on the system (Fig. 3) as proposed by Vavrous et al. . This column, possessing the same chemistry as the separative one, was connected between the solvent mixing chamber and the injector of the LC apparatus then set in the column oven.
- Is DEHP contamination from LC system favored by a mobile phase?
- After deep investigation, we concluded that DEHP contamination came from the LC system and was favored by using a mobile phase with a high content of ACN. In order to discriminate DEHP contamination and DEHP present in the sample, a trap column was implemented on the system (Fig. 3) as proposed by Vavrous et al. .
