Lower achieved SBP and DBP associated with more CV events
Main results. The lowest risk for the combined primary outcome as well as CV death, hospital admission for HF and all-cause death, was seen at a baseline SBP of 120-140 mmHg. Those with SBP >140 mmHg or SBP
Lower achieved SBP and DBP associated with more CV events
Main results The lowest risk for the combined primary outcome as well as CV death, hospital admission for HF and all-cause death, was seen at a baseline SBP of 120-140 mmHg. Those with SBP >140 mmHg or SBP
When diastolic BP falls below 55 mmHg, the risk of CV events
In this analysis of SPRINT (Systolic Blood Pressure Intervention Trial), the relationship between lower systolic (SBP) and diastolic BP (DBP) and the risk for CV events was examined in those with and without CV disease. Moreover, clinical predictors for developing low diastolic BP were investigated.
Older Adults and Hypertension: Beyond the 2017 Guideline
However, regardless of initial DBP, intensive SBP lowering was associated with lower CV event rates. 16 Even in the lowest DBP quintile (
Blood pressure and cardiovascular outcomes in patients with
In patients with diabetes and elevated CV risk, even after extensive adjustment for underlying disease burden, there was a persistent association for low DBP with subclinical myocardial injury and risk of MI. Open in a separate window Keywords: Hypertension, Diabetes, Blood pressure, Biomarkers Introduction
- Is a low blood pressure target a risk factor for CV events?
- Findings from SPRINT (Systolic Blood Pressure Intervention Trial) in 2015 demonstrated that an intensive SBP target of <120 mm Hg resulted in fewer CV events and deaths than a standard SBP target of <140 mm Hg ( 4). More aggressive SBP reduction is associated with higher risk of CV events in patients with lower DBP (5, 6, 7, 8, 9 ).
- Does lowering SBP increase cardiovascular events?
- In the standard treatment group, lowering SBP to ≤120 mm Hg was associated with a nonsignificant increase in cardiovascular events compared with achieved SBP of 121 to 150 mm Hg in the standard arm (HR, 1.38; 95% CI, 0.92–2.06).
- Does SBP increase risk of cardiovascular events in Ta patients?
- In the intensive-treatment group, patients failing to achieve SBP targets presented higher cardiovascular risk than those TA patients (HR 2.04, 95% CI 1.44-2.88; P < 0.001). A J-shaped relationship was observed between the mean achieved SBP and risk of cardiovascular events, with the lowest risk at an SBP of 126.9 mmHg.
- What is the relationship between SBP & DBP?
- For example, SBP/DBP of 140-155/70-80 mm Hg was associated with the lowest HR for all-cause mortality, compared with 110-120/85-90 mm Hg for MI and 125-135/70-75 mm Hg for CHF. In contrast, the association of SBP and stroke was linear. The risk pattern of SBP and DBP differs by clinical outcomes, and the SBP and DBP associated with the lowest risk.
- Are SBP and DBP associated with cardiovascular events?
- SBP and DBP have important associations with cardiovascular events, but are seldom considered simultaneously.
- What is the relationship between follow-up SBP and primary outcome?
- In the model without diastolic pressure, the relationship between follow-up SBP and the primary outcome was nonlinear (P =0.03), although a distinct J-shaped relationship was only observed in the standard group (Figure S1 in the online-only Data Supplement).
