Risk Evaluation for Di-isononyl phthalate (DINP) (1,2-Benzene
(202) 564-370 EPA granted the manufacturer request for risk evaluation for di-isononyl phthalate (DINP) (1,2-benzenedicarboxylic acid, 1,2-isononyl ester) in December 2025, and this category of chemicals is currently undergoing risk evaluation. Learn more about manufacturer-requested risk evaluations.
Manufacturer-Requested Risk Evaluation of Diisononyl
Manufacturer-Requested Risk Evaluation of Diisononyl Phthalate (DINP) Documents supporting the TSCA section 6 manufacturer request for risk evaluation submitted by ExxonMobil Chemical Company, Evonik Corporation, and Teknor Apex, through the American Chemistry Council’s High Phthalates Panel, are provided below.
Di-isononyl Phthalate (DINP); Final Scope of the Risk
Di-isononyl Phthalate (DINP) (1,2-Benzene- dicarboxylic acid, 1,2-diisononyl ester); Manufacturer Request for Risk Evaluation Under the Toxic Substances Control Act (TSCA); Notice of Availability and Request for Comments. Federal Register. ( 84 FR 42912, August 19, 2025) (FRL-9998-25). 2. EPA.
EPA TSCA Manufacturer-Requested Risk Evaluations (MRREs)
MRREs of DINP and DIDP. In May of 2025, ACC’s High Phthalates Panel (ACC HPP), representing major producers, importers, and users of diisononyl phthalate (DINP), diisodecyl phthalate (DIDP), and other high molecular weight phthalates, submitted a request for an EPA risk evaluation of DINP and a request for an EPA risk evaluation of DIDP.
Di-isononyl Phthalate (DINP); Manufacturer Request for Risk
Response: This manufacturer request for evaluation was made specifically for DINP (CASRNs 28553-12-0 and 68515-48-0), not other chemicals or other phthalates. Since EPA’s authority to conduct a manufacturer-requested risk evaluation is tied to the “chemical substance . . . that a
- When did EPA release a risk evaluation for diisononyl phthalate (DINP)?
- In January 2025, EPA released the final risk evaluation under the Toxic Substances Control Act (TSCA) for diisononyl phthalate (1,2-benzenedicarboxylic acid, 1,2-isononyl ester) (DINP). EPA granted the manufacturer request for risk evaluation for DINP in December 2019. Learn more about manufacturer-requested risk evaluations.
- Is Di-isononyl phthalate (DINP) benzenedicarboxylic acid a risk?
- EPA granted the manufacturer request for risk evaluation for di-isononyl phthalate (DINP) 1,2-benzenedicarboxylic acid, 1,2-isononyl ester in December 2019 and the chemical is currently undergoing risk evaluation.
- When will EPA release the final risk evaluation for DINP?
- In January 2025, EPA released the final risk evaluation for DINP. EPA will now begin the risk management process to address the unreasonable risk presented by DINP. EPA will release a proposed rule under TSCA section 6 to protect workers from the identified risks.
- Does DINP cause phthalate syndrome?
- Therefore, EPA is including DINP in its cumulative risk analysis for six phthalates that demonstrate effects consistent with phthalate syndrome. Workers may be exposed to DINP when making products or otherwise using DINP in the workplace.
- Is DINP harmful to human health?
- EPA has determined that DINP presents and unreasonable risk of injury to human health. DINP can cause developmental toxicity and harm the liver and can cause cancer at higher rates of exposure.
