Metabolism and urinary excretion kinetics of di(2-ethylhexyl
Metabolism and urinary excretion kinetics of di (2-ethylhexyl) adipate (DEHA) in four human volunteers after a single oral dose Authors Alexandra Nehring 1 , Daniel Bury 2 , Benedikt Ringbeck 3 , Hans-Willi Kling 4 , Rainer Otter 5 , Tobias Weiss 6 , Thomas Brüning 7 , Holger M Koch 8 Affiliations
Di-(2-ethylhexyl) phthalate substitutes accelerate human
The obesity pandemic is presumed to be accelerated by endocrine disruptors such as phthalate-plasticizers, which interfere with adipose tissue function. With the restriction of the plasticizer di-(2-ethylhexyl)-phthalate (DEHP), the search for safe substitutes gained importance.
Di-(2-ethylhexyl) phthalate substitutes accelerate human
The obesity pandemic is presumed to be accelerated by endocrine disruptors such as phthalate-plasticizers, which interfere with adipose tissue function. With the restriction of the plasticizer di-(2-ethylhexyl)-phthalate (DEHP), the search for safe substitutes gained importance. Focusing on the mast
Simultaneous and sensitive determination of the main
With the prominent but toxicologically critical plasticizer di-(2-ethylhexyl) phthalate (DEHP) declining, alternative plasticizers are increasingly used leading to a continuously more diverse exposure situation of humans with multiple plasticizers. Therefore, an on-line SPE-LC-MS/MS method for the simultaneo
Secondary oxidized di-2-ethylhexyl phthalate metabolites may
Phthalate esters (PAEs) may act as estrogen receptor agonists, and their relationship with precocious puberty is a global health concern. However, their role in isolated premature thelarche (IPT
- What is di-2-ethylhexyl phthalate (DEHP)?
- Provided by the Springer Nature SharedIt content-sharing initiative Di- (2-ethylhexyl) phthalate (DEHP) is one of the most widely used plasticizers. Many studies focus on the impact of continuous exposure to DEHP on humans a
- Is di-2-ethylhexyl phthalate a plasticizer?
- Di-2-ethylhexyl phthalate is a plasticizer of health concern due to its presence in the environment and its association with health issues such as metabolic and neurodevelopment disorders. We review the potential hazards and mechansims of di-2-ethylhexyl phthalate exposure on the metabolism and neurodevelopment.
- Does di-2-ethylhexyl phthalate interact with rice plants?
- Di- (2-ethylhexyl) phthalate (DEHP) as widely utilized plasticizer has aroused increasing concerns since its endocrine disrupting effects and continuous accumulation in biota. To date, the interaction mechanism between DEHP and rice plants has not been clearly illustrated at molecular level.
- How does di-2-ethylhexyl phthalate affect metabolism?
- Di-2-ethylhexyl phthalate is closely linked to metabolic diseases such as obesity and diabetes, interfering with adipocyte differentiation and lipid metabolism through multiple pathways, thereby disrupting the energy balance. Di-2-ethylhexyl phthalate is also altering the pancreatic function and glucose metabolism.
- Does di- (2-ethylhexyl phthalate) cause obesity?
- Chemosphere 35:667–749 Su HH, Yuan PH, Lei HH, Zhang L, Deng DZ, Zhang LM, Chen XY (2022) Long-term chronic exposure to di- (2-ethylhexyl)-phthalate induces obesity via disruption of host lipid metabolism and gut microbiota in mice.
- How do microplastics and Di (2-ethylhexyl phthalate synergistically induce APOP?
- Wang YQ, Zhang YL, Sun XY, Shi X, Xu SW (2022) Microplastics and di (2-ethylhexyl) phthalate synergistically induce apoptosis in mouse pancreas through the GRP78/CHOP/Bcl-2 pathway activated by oxidative stress. Food Chem Toxicol 167:12
