Migrability of PVC plasticizers from medical devices into a
Migrability of PVC plasticizers from medical devices into a simulant of infused solutions Medical devices (MD) for infusion and artificial nutrition are essentially made of plasticized PVC. The plasticizers in the PVC matrix can leach out into the infused solutions and may enter into contact with the patients.
Migrability of PVC plasticizers from medical devices into a
Our study aimed to determine the migratabality of the main alternative plasticizers used in PVC medical devices for infusion and artificial nutrition (TOTM, DEHT, and DINCH), and to compare them to that of DEHP, the reference plasticizer up to 2010 when its use in MDs was restricted.
Migrability of PVC plasticizers from medical devices into a
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Migration of plasticizers from PVC medical devices
Alternatives to DEHP plasticizers are used in various PVC medical devices (MD) for infusion. As they are able to migrate from these MDs into infused solutions, they may come into contact with patient. Different and specific clinical parameters influence their migration in at-risk situations such as infusion.
Effects of flow rate on the migration of different
The migrability of the plasticizers is dependent of several clinical parameters such as temperature, contact time, nature of the simulant, etc… However, no data is available about the influence of the flow rate at which drug solutions are administrated.
- Are plasticizers in the PVC matrix a risk factor for patient exposure?
- The plasticizers in the PVC matrix can leach out into the infused solutions and may enter into contact with the patients. In order to assess the risk of patient exposure to these plasticizers we evaluated the migration performance of DEHP, DEHT, DINCH, and TOTM using a model adapted to the clinical use of the MDs.
- Are PVC plasticizers harmful to patients?
- The plasticizers in the PVC matrix can leach out into the infused solutions and may enter into contact with the patients. In order to assess the risk of patient exposure to these plasticizers we evalu … Migrability of PVC plasticizers from medical devices into a simulant of infused solutions Int J Pharm.
- Why is plasticizer migration a problem?
- The plasticizer migration from the plastic item to its surroundings may involve the appearance of problems, namely the modification of flexibility of the PVC and the contamination of the media in contact with PVC.
- Why is extraction and migration of PVC plasticizers important?
- Exudation under pressure. The study of the extraction and migration of PVC plasticizers is of great importance for different reasons. Extraction of the plasticizer can occur in PVC films in contact with food, in bags or pipes in contact with biological fluids, such as blood, or even when a child could chew a PVC toy.
- Can PVC plasticizers migrate to a polymer in contact with flexible PVC?
- The ability of different PVC plasticizers to migrate towards a polymer in contact with flexible PVC has been investigated. A procedure based on the monitoring of the plasticizer concentration by infrared spectroscopy has been employed.
- How PVC plasticizers are extracted?
- Volatilization from the PVC surface to the air. Extraction from PVC to a liquid in contact with it. Migration from PVC to a solid or semi-solid in contact with it. Exudation under pressure. The study of the extraction and migration of PVC plasticizers is of great importance for different reasons.
