DEHT is a suitable plasticizer option for phthalate-free
Abstract. Background and objectives: Due to increasing concerns about possible endocrine-disrupting properties, the use of the plasticizer di (2-ethylhexyl) phthalate (DEHP) will be banned in future blood storage. Di (2-ethylhexyl) terephthalate (DEHT) provides sufficient red blood cell (RBC) quality during conventional blood bank storage.
Non-phthalate plasticizer DEHT preserves adequate blood
Non-phthalate plasticizer DEHT preserves adequate blood component quality during storage in PVC blood bags Our study demonstrates that the plasticizer DEHT provides adequate blood component quality. We propose DEHT as a strong future candidate for replacement of DEHP in blood bags.
Non-Phthalate Plasticizer Performs Comparably in Blood Bag Study
A recent study demonstrates that a non-phthalate plasticizer performs comparably to a phthalate plasticizer when used in red blood cell storage bags. The non-phthalate plasticizer, Eastman 168 SG, was studied at the Blood Center of Wisconsin, reported Mark Brucks, market development manager, plasticizers, for Eastman.
Non‐phthalate plasticizer DEHT preserves adequate blood component
Polyvinyl chloride (PVC) plasticized with di(2-ethylhexyl) phthalate (DEHP) has been the material of choice for commercial blood containers since the mid-20th century. Plasticizers are essential for material flexibility; facilitating centrifugation, sealing, transport and general handling of blood bags without risk of breakage and product loss [ 1 ].
Non‐phthalate plasticizer DEHT preserves adequate blood component
Background and objectives Commercial blood bags are predominantly made of polyvinyl chloride (PVC) plasticized with di(2-ethylhexyl) phthalate (DEHP). DEHP is favourable for storage of red blood cells (RBC). Historically, removal of DEHP from blood bags has been linked to unacceptable haemolysis levels.
- Are PVC-DEHT blood bags phthalate?
- PVC-DEHT bags hold as high physical and functional quality as bags plasticized with DEHP. Therefore, we consider PVC-DEHT blood bags a recommendable non-phthalate candidate for future blood component collection and storage. Walter CW: Invention and develop-ment of the blood bag.
- Can plasticizer DEHT replace DEHP in blood bags?
- Conclusion: Our study demonstrates that the plasticizer DEHT provides adequate blood component quality. We propose DEHT as a strong future candidate for replacement of DEHP in blood bags. Keywords: DEHP; DEHT; blood components; phthalates; plasticizers; red blood cells. © 2020 The Authors.
- Do PVC blood bags plasticized with DEHT provide adequate red blood cell quality?
- As a future aspect, the individual contribution of different pro-duction parameters should be further explored. In conclusion, this study demonstrates that PVC blood bags plasticized with DEHT provide adequate red blood cell quality during 49 days of storage.
- Does plasticizer DEHT provide adequate blood component quality?
- The metabolic parameters were not influenced by choice of plasticizer. Platelet activation/metabolism and plasma content were similarly preserved. Conclusion: Our study demonstrates that the plasticizer DEHT provides adequate blood component quality.
- What is a plastic blood bag?
- Plastic materials are based on polymers, which are large molecules built up by the repetition of small, simple chemical units (monomers). Polymers alone are of little value and must be compounded with various additives to make a useful material, or plastic. This is particularly true of PVC plastic, by far the most widely used blood bag material.
- Which blood bags are made of PVC-DEHT / DEHP?
- Prototype blood bags made entirely of PVC-DEHT or PVC-DEHP, respectively (including tubes, ports and fil-ters), were manufactured for the study (Macopharma, Mouvaux, France), mimicking the commercially available quintuple bottom-and-top NPT reference (bag configura-tion: Supporting Information 1).
