Subacute exposure to di-isononyl phthalate alters the morphology
Di-isononyl phthalate (DiNP), a common plasticizer used in polyvinyl chloride products, exhibits endocrine-disrupting capabilities. It is also toxic to the brain, reproductive system, liver,...
Occupational exposure to diisononyl phthalate (DiNP) in polyvinyl
The National Institute for Occupational Safety and Health (NIOSH) conducted a pilot study in 2003–2005 to screen occupational populations for exposure to diethyl phthalate (DEP), dibutyl phthalate (DBP), and DEHP using urinary phthalate metabolites as exposure biomarkers (Hines et al. 2009 ).
Occupational Exposure of Plastics Workers to Diisononyl Phthalate (DiNP
Low-level occupational exposure to DiNP was observed in the company that produced coated textiles—out of eight workers, one extruder operator was exposed to DiNP at levels exceeding the non-occupationally exposed population background levels. Some workers in the cable factory and the plastics producing company were occupationally exposed to DPHP.
Decrease in serum testosterone levels after short-term occupational
Decrease in serum testosterone levels after short-term occupational exposure to diisononyl phthalate in male workers.
Decrease in serum testosterone levels after short-term occupational
In practice, the substitution of DEHP with DINP in the soft polyvinyl chloride industrial sector could be questioned. ABSTRACT Objective The objective of the study was to examine the effects of occupational exposure to diisononyl phthalate (DinP) on serum testosterone levels in male workers. Methods From 2015 to 2018, 97 male workers were
- Is diisononyl phthalate toxic?
- EPA released the final risk evaluation for diisononyl phthalate (DINP) under the Toxic Substances Control Act (TSCA).
- What is diisononyl phthalate (DINP)?
- Diisononyl phthalate (DINP) is a dialkyl phthalate plasticizer that has been used in children's products made from polyvinyl chloride (PVC), such as teethers and toys. It is one of the plasticizers that can migrate from children's toys, child care articles, art materials, and school supplies.
- Is DINP a risk factor for phthalate syndrome?
- Therefore, EPA is including DINP in its cumulative risk analysis for six phthalates that demonstrate effects consistent with phthalate syndrome. This draft risk analysis was released earlier this month.
- How will EPA address the unreasonable risk presented by DINP?
- EPA will now begin the risk management process to address the unreasonable risk presented by DINP. EPA will release a proposed rule under TSCA section 6 to protect workers from the identified risks. Read the final risk evaluation for DINP.
- Why is DINP dangerous?
- EPA has determined that DINP presents an unreasonable risk of injury to human health, because workers could be exposed to high concentrations of DINP in mist when spraying adhesive, sealant, paint, and coating products that contain DINP. DINP can cause developmental toxicity and harm the liver and can cause cancer at higher rates of exposure.
- Did EPA conduct a risk evaluation for DINP?
- EPA conducted the risk evaluation for DINP at the manufacturer’s request. Under TSCA, manufacturers can request that EPA conduct risk evaluations on chemicals they manufacture. EPA received and granted this manufacturer request for a risk evaluation of DINP in 2019.
