[PDF] Pharmaceutically Used Plasticizers | Semantic Scholar
Although there are many plasticizers used in the chemical industry, only a few of them have been approved for pharmaceutical applications. The natural-based plasticizers characterized by low toxicity and low migration are required nowadays not only for pharmaceutical and medical… View via Publisher intechopen.com Save to Library Create Alert Cite
Pharmaceutically Used Plasticizers | IntechOpen
Pharmaceutically Used Plasticizers Written By Eva Snejdrova and Milan Dittrich Submitted: November 11th, 2011 Published: March 21st, 2012 DOI: 10.5772/39190 IntechOpen From the Edited Volume Recent Advances in Plasticizers Edited by Mohammad Luqman Book Details Order Print Chapter metrics overview 26,853 Chapter Downloads View Full Metrics
PHARMACEUTICALLY USED PLASTICIZERS: A REVIEW - ResearchGate
The concentration of plasticizer affects the strength of coating films, overall integrity of drug products and drug release characteristics in therapeutic pharmaceutical dosage forms. 1, 2 The...
PHARMACEUTICALLY USED PLASTICIZERS: A REVIEW
an overview of the important types of plasticizers which exist, and gives details of properties of the plasticizers. The choice of an appropriate plasticizer requires a wide background of information.
6,100 167,000 185M
Recent Advances in Plasticizers 46 2. Pharmaceutically used plasticizers The primary role of all plasticizers as low molecular weight non-volatile additives is to improve the flexibility and processability of polymers by lowering the second order transition temperature (glass transition temperature, Tg) (Rosen, 1993). The extent of Tg
- Are plasticizers suitable for pharmaceutical applications?
- The extensive use of polymers in medical and pharmaceutical applications including particularly packaging, medical devices, drug carriers and coatings has caused a substantial demand for the proper plasticizers. Although there are many plasticizers used in the chemical industry, only a few of them have been approved for pharmaceutical applications.
- Are polymeric drug delivery systems plasticizers?
- Plasticizer as minor component of polymeric drug delivery systems has not been strictly defined. Even liquid drugs or liquids with a potential pharmacodynamic effect can serve as plasticizers. As well structural water in the hydrophilic polymer seems to be an internal plasticizer of the polymeric drug delivery systems.
- Is hydrophilic polymer an internal plasticizer of polymeric drug delivery systems?
- As well structural water in the hydrophilic polymer seems to be an internal plasticizer of the polymeric drug delivery systems. In case of contact with body fluids after application the hydrophilic plasticizer can be released from polymer and thus conditions for the incorporated drug release are changed.
- Are natural-based plasticizers suitable for pharmaceutical and medical applications?
- The natural-based plasticizers characterized by low toxicity and low migration are required nowadays not only for pharmaceutical and medical applications. In this respect, most of traditional plasticizers are not applicable in this area.
- Which polymers are used in drug delivery systems?
- Aliphatic polyesters are the most frequently used polymers in drug delivery systems. Star-like copolymers of hydroxy acids with polyhydric alcohols such as dipentaerythritol are particularly interesting. They possess good mechanical properties, however the brittleness is their major drawback for many applications.
- Which substances were used as plasticizers?
- Oily, waxy, or fatty substances were applied as plasticizers. Other invention relates to an oral pulse release comprising a polymer micromatrix, a first active ingredient distributed substantially uniformly within polymer micromatrix and a second active ingredient deposited on the surface of the polymer matrix (Gadre et al., 2006).
