Full article: A review of phthalate pharmacokinetics in human and rat
The number of experimental studies on phthalate pharmacokinetics published per decade was relatively stable in the 1970s and the 1980s, decreased in the 1990s, and has increased since the 2000s. These experiments consisted generally of in-vivo studies of the pharmacokinetics of DEHP and DBP in
Pharmacokinetics of dibutyl phthalate (DBP) in the rat determined by
The pharmacokinetic results demonstrate that DBP appeared to have a two-compartment model in the rats; the area under concentration versus time (AUC) was 57.8 ± 5.93 min μg/mL and the distribution and elimination half-life (t (1/2,α) and t (1/2,β)) were 5.77 ± 1.14 and 217 ± 131 min, respectively, after DBP administration (30 mg/kg, i.v.).
Pharmacokinetics of Dibutyl Phthalate (DBP) in the Rat Determined by
The pharmacokinetic results demonstrate that DBP appeared to have a two-compartment model in the rats; the area under concentration versus time (AUC) was 57.8 ± 5.93 min μg/mL and the distribution and elimination half-life (t 1/2,α and t 1/2,β) were 5.77 ± 1.14 and 217 ± 131 min, respectively, after DBP administration (30 mg/kg, i.v.).
Pharmacokinetics of Dibutyl Phthalate (DBP) in the Rat Determined by
Keywords: dibutyl phthalate (DBP); liquid chromatography with tandem mass spectrometry (LC-MS/MS); pharmacokinetics; plasticizer 1. Introduction Phthalate ester derivatives have been used as plasticizers in a wide variety of plastic products, such as children’s toys, medical devices and various types of packaging [1]. However, in some illegal
Pharmacokinetics of dibutyl phthalate (DBP) in the rat determined by
Pharmacokinetics of dibutyl phthalate (DBP) in the rat determined by UPLC-MS/MS. Sign in | Create an account. https://orcid.org. Europe PMC
- What is dibutyl phthalate (DBP)?
- DBP is a phthalate with the same core structure as DIDP and DINP but with two shorter side chains attached, each having four carbon atoms. It is also referred to as '1,2-benzenedicarboxylic acid, dibutyl ester (9CI)'
- What is dibutyl phthalate (DDD)?
- Dibutyl phthalate, also known as DBP or DDD, is a colorless to faint yellow, oily liquid. Its total production volume in the United States ranges between 1 million and 10 million pounds.
- What is Diisobutyl phthalate (DIBP) concentration?
- Diisobutyl phthalate (DIBP): 0.1% (added in 2015). It shall be noted that above maximum concentration values apply to each homogeneous material rather than a product or a part itself. A homogeneous material means material of uniform composition throughout that cannot be mechanically separated into different materials.
- Is dibutyl phthalate toxic?
- Dibutyl phthalate is subject to reporting to EPA’s Toxics Release Inventory (TRI) and is considered a substance of concern. For the 2018 reporting year, 61 facilities reported releases of dibutyl phthalate to air, water, and via land disposal to the EPA.
- How is dibutyl phthalate produced?
- Dibutyl phthalate is produced through the esterification of the carboxyl groups of dibutyl phthalate with n-butyl alcohol in the presence of sulfuric acid as a catalyst (ECHA, 2009). After the esterification reaction, excess alcohol is recovered and dibutyl phthalate is purified through distillation or activated charcoal (ECHA, 2009).
- Is dibutyl phthalate regulated in the United States?
- Dibutyl phthalate is subject to federal and state laws and regulations in the United States (Table_Apx D-1 and Table_Apx D-2).
