Pharmacokinetics of Dibutyl Phthalate (DBP) in the Rat
Dibutyl phthalate (DBP) is commonly used to increase the exibility of plastics in industrial products. However, several plasticizers have been illegally used as clouding agents to increase dispersion of aqueous matrix in beverages. This study thus develops a rapid and validated analytical method by ultra-performance liquid chromatography with tandem mass spectrometry (UPLC-MS/MS) for the
Pharmacokinetics of dibutyl phthalate (DBP) in the rat
The pharmacokinetic results demonstrate that DBP appeared to have a two-compartment model in the rats; the area under concentration versus time (AUC) was 57.8 ± 5.93 min μg/mL and the distribution and elimination half-life (t (1/2,α) and t (1/2,β)) were 5.77 ± 1.14 and 217 ± 131 min, respectively, after DBP administration (30 mg/kg, i.v.).
Pharmacokinetics of Dibutyl Phthalate (DBP) in the Rat
(UPLC-MS/MS) to measure DBP in rat plasma and feces in free moving male rats. This method is then applied to the pharmacokinetics of DBP and its unabsorbed fecal elimination. 2. Results and Discussion 2.1. LC–MS/MS and Method Validation In order to improve the detection of DBP, the UPLC–MS/MS condition has been optimized and validated by
Pharmacokinetics of dibutyl phthalate (DBP) in the rat
Pharmacokinetics of dibutyl phthalate (DBP) in the rat determined by UPLC-MS/MS. Sign in | Create an account. https://orcid.org. Europe PMC. Menu. About. About Europe
A review of phthalate pharmacokinetics in human and rat: what
Four processes are particularly relevant to phthalate distribution: protein binding, ionization, passive partitioning, and metabolism in different tissues. The interplay of these processes needs to be better represented in methods for determining the PC values of phthalates. The hydrophobicity of phthalates affects all pharmacokinetic steps.
- What is the distribution and accumulation of dibutyl phthalate (DBP)?
- Dibutyl phthalate (DBP) is mainly taken up by the general population from food intake. To estimate intake of phthalates, determining distribution and accumulation of DBP in biological materials was a critical need.
- What is the distribution and accumulation of DBP in vivo?
- This data give directly evidence that indicates the distribution and accumulation of DBP in vivo. Double-label immunofluorescence assay provides with a visual approach to determination of the distribution and accumulation of DBP. It indicated that DBP accumulated in subcutaneous tissue such as sweat gland, hair follicle.
- What are the toxicity kinetics of DIBP?
- Toxicokinetics of DiBP were characterized by extensive distribution, short half-life, and high clearance. DiBP was rapidly metabolized to MiBP, with MiBP levels consistently exceeding the DiBP levels. Distribution of MiBP to tissues was considerable.
- How is DIBP metabolized to MIBP?
- DiBP was rapidly metabolized to MiBP, with MiBP levels consistently exceeding the DiBP levels. Distribution of MiBP to tissues was considerable. The developed analytical method satisfied international criteria and was successfully applied to toxicokinetic studies after oral and intravenous administration of DiBP to rats.
- What is the toxicity of DIBP compared to MIBP?
- The developed assay had lower limits of quantification of 0.01 ng/mL for DiBP and 0.1 ng/mL for MiBP at all biological matrices. Toxicokinetics of DiBP were characterized by extensive distribution, short half-life, and high clearance. DiBP was rapidly metabolized to MiBP, with MiBP levels consistently exceeding the DiBP levels.
