High-fat diet aggravates prenatal low-dose DEHP exposure
High-fat diet aggravates prenatal low-dose DEHP exposure induced spermatogenesis disorder: Characterization of testicular metabolic patterns in mouse offspring High-fat diet aggravates prenatal low-dose DEHP exposure induced spermatogenesis disorder: Characterization of testicular metabolic patterns in mouse offspring
Plasticizer At High Doses Disrupts Male Reproductive Function
Research at CIIT indicates the plasticizer di (n-butyl)phthalate (DBP) at high doses disrupts a variety of reproductive functions in male rats when exposed in the womb during late...
Plastic additive linked to excessive reproductive abnormalities
For years, scientists have linked exposure to DEHP, short for di (2-ethylhexyl) phthalate — a chemical added to many plastics to make them flexible — to increased risk of health problems, including reproductive abnormalities such as birth defects and male infertility.
Dose-Dependent Alterations in Androgen-Regulated Male
Abstract. Di(n-butyl) phthalate (DBP) is a commercially important plasticizer and ubiquitous environmental contaminant.Since previous, limited dose-response studies with DBP that reported alterations in male reproductive development and function failed to establish a NOAEL (no-observed-adverse-effect level), an extensive dose-response study was conducted.
The plasticizer diethylhexyl phthalate induces malformations
Abstract Phthalate esters (PE) such as DEHP are high production volume plasticizers used in vinyl floors, food wraps, cosmetics, medical products, and toys. In spite of their widespread and long-term use, most PE have not been adequately tested for transgenerational reproductive toxicity.
- Does plasticizer exposure affect male and female reproductive health?
- Results indicate that exposure to phthalates and bisphenol can adversely affect male and female reproductive health. However, evidence is still controversial. More large-scale prospective cohort studies are needed to verify the effects of plasticizer exposure on reproductive health in humans.
- Are plasticizers harmful?
- Thus, exposure to these compounds is of concern due to potential adverse health effects. Most plasticizers currently used in the plastics industry are phthalates, in particular, 2-ethylhexyl phthalate (DEHP) which, along with its metabolites, has been shown to affect the testis with its anti-androgenic proprieties 6, 10.
- Do plasticizers impede development?
- Despite these endocrinological changes, no changes in the glucocorticoid receptor mRNA were found in either sex. In summary, plasticizers impede with development by disrupting the expression of TH-related genes, by binding to TRs, by influencing THs levels, and by enhancing the interactions between TR and a co-repressor. 4.4.
- Is phthalate exposure associated with hypospadias in male births?
- Overall, evidence from the epidemiological studies that estimate the association between phthalate exposure and hypospadias in male births is limited and inconclusive. Higher levels of phthalates have been found in women than in men, which revealed an aggregated phthalate exposure in females.
- Should phthalate exposure be reduced among reproductive-aged women?
- It is necessary to reduce phthalate exposure among reproductive-aged women as much as possible. Phthalate exposure is also associated with other aspects of reproductive health or has adverse effects.
- Are DEHP-alternative plasticizers cytotoxic?
- In vitro cytotoxic effects of DEHP-alternative plasticizers and their primary metabolites on a L929 cell line. Chemosphere 173, 452–459, doi: 10.1016/j.chemosphere.2017.01.026 (2017).
