Plasticizer extraction of Taxol infusion solution
Taxol solution extracts the plasticizer DEHP (di(2-ethylhexyl)phthalate) from polyvinyl chloride (PVC) materials. In order to minimize patient exposure to DEHP, Taxol solutions should be prepared and administered in PVC-free materials. Particulate matter may form in Taxol infusion solution over time
Plasticizer extraction of Taxol-infusion solution
Taxol solution extracts the plasticizer DEHP (di (2-ethylhexyl)phthalate) from polyvinyl chloride (PVC) materials. In order to minimize patient exposure to DEHP, Taxol solutions should be prepared and administered in PVC-free materials.
Plasticizer extraction of Taxol-infusion solution
The four tested administration-sets labeled as PVC-free, were all found to be suitable for Taxol application and the tested standard PVC-lined administration-set should not be used for taxol, application. Taxol solution extracts the plasticizer DEHP (di(2-ethylhexyl)phthalate) from polyvinyl chloride (PVC) materials. In order to minimize patient exposure to DEHP, Taxol solutions should
Stability, compatibility, and plasticizer extraction of taxol
A taxol formulation consisting of a 6-mg/mL solution of taxol in 50% polyoxyethylated castor oil and 50% dehydrated ethanol was added to 50- and 100-mL glass bottles, PVC infusion bags, and polyolefin containers containing 5% dextrose injection or 0.9% sodium chloride injection to give initial nominal taxol concentrations of 0.3, 0.6, 0.9, and
A Submicron Lipid Emulsion Coated with Amphipathic
Paclitaxel is a promising anticancer agent with poor solubility in water and requires a suitable formulation for intravenous administration. Presently paclitaxel is formulated for clinical use in ethanol and Cremophor EL (Diluent 12), a solvent system associated with severe adverse effects.
- Can taxol be administered in PVC-free materials?
- In order to minimize patient exposure to DEHP, Taxol solutions should be prepared and administered in PVC-free materials. Particulate matter may form in Taxol infusion solution over time, so that in-line filtration with microporous membranes not greater than 0.22 microns is advisable.
- Is in-line filtration suitable for Taxol application?
- Particulate matter may form in Taxol infusion solution over time, so that in-line filtration with microporous membranes not greater than 0.22 microns is advisable. The purpose of this study was to evaluate the suitability of various administration- and in-line filter-sets for Taxol application.
- What is Taxol solution?
- 1 Apotheke, Klinikum J. Gutenberg Universität, Mainz, Germany. Taxol solution extracts the plasticizer DEHP (di (2-ethylhexyl)phthalate) from polyvinyl chloride (PVC) materials. In order to minimize patient exposure to DEHP, Taxol solutions should be prepared and administered in PVC-free materials.
- How is Taxol given?
- Taxol should be administered under the supervision of a physician experienced in the use of cancer chemotherapeutic agents. It is important that appropriate management of complications is possible when diagnostic and treatment facilities are readily available.
- Does paclitaxel TM contain cremophor and ethanol?
- Paclitaxel injection (Taxol TM) contains cremophor and ethanol in equal proportions, two agents known to leach diethylhexylphthalate (DEHP) from polyvinyl chloride (PVC) infusion bags and administration sets. The manufacturers of paclitaxel therefore recommend the use of glass, polypropylene or polyolefin containers for storage.
- Does Taxol (nsc-125973) Leach di (2-ethylhexyl) phthalate?
- The stability of taxol (NSC-125973) in various diluents and containers was determined, and the extent of leaching of DEHP (di (2-ethylhexyl) phthalate) from PVC bags caused by the taxol formulation was measured.
