Plasticizers from Plastic Devices: Extraction, Metabolism
One such plasticizer was metabolized by the isolated perfused rat liver while another was found to be accumulated in the liver unchanged. In addition, this latter plasticizer was identified in samples of human tissue taken from patients who had received transfusions of blood stored in plastic bags.
Plasticizers from Plastic Devices: Extraction, Metabolism
Plasticizers from Plastic Devices: Extraction, Metabolism, and Accumulation by Biological Systems Created Date: 20160807140232Z
Plasticizers from plastic devices extraction, metabolism, and
Plasticizers from plastic devices extraction, metabolism, and accumulation by biological systems Phthalate ester plasticizers were found to be extracted by blood from plastic tubing and from plastic bags used for blood storage.
Contents | Science 170, 3956
Plasticizers from Plastic Devices: Extraction, Metabolism, and Accumulation by Biological Systems ... Phthalate ester plasticizers were found to be extracted by blood
Extraction, Localization, and Metabolism of Di-2-Ethylhexyl
Table 1. Extraction of plasticizers from two types of medical devices.a Plasticizer concentration, Circulation mg! 100 ml blood Medical device time. hr DEHP DEHA Travenol hemo- 0 7.75 0 dialysis unit 8 9.24 2.14 Travenol cardio- 0 5.04 0 pulmonary by- 2.5 5.28 2.34 pass unit 5 5.70 4.99 aData of Jaeger (1). 96 Environmental Health Perspectives
- Are plasticizers toxic?
- Plasticizers are compounds added to plastics and can be released to the environment under certain conditions. Toxicological studies have concluded that plasticizers, phthalates, and bisphenols are endocrine disruptors, alter the endocrine system and functioning of the immune system and metabolic process.
- Are plasticizers endocrine disrupting chemicals?
- Many of the used plasticizers are suspected to be endocrine disrupting chemicals (EDCs), exhibiting carcinogenic action ( Gallo et al., 2018, Mathieu-Denoncourt et al., 2015, Somashekar et al., 2015 ).
- Can plasticizers be substituted for biodegradable chemicals?
- Therefore, possible substitutions of currently used plasticizers have been speculated for a new class safer both for the environment and human health, as biodegradable chemicals. A special focus on those chemicals that do contact with food, body fluids, lubricating oils, or fuels is critically needed.
- Why do plasticizers migrate to other contacting media?
- Because of the incorporation of plasticizers into polymer matrix is physical, rather than chemical, makes them easily leached and migrate to other contacting media ( Somashekar et al., 2015, Strungaru et al., 2019 ).
- Are plasticizers toxic to erythrocytes?
- Accordingly, the toxic effect of plasticizers on erythrocytes ( Table 1) has been evidenced in several reports with potential biochemical and structural changes ( Bicalho et al., 2016, Draper et al., 2002, Melzak et al., 2018, Münch et al., 2019 ).
- What are plastic products made of?
- Most plastic products are made from the essential polymer mixed with a complex blend of materials known collectively as additives or plasticizers that provide plastics greater flexibility and durability for high performing applications.
