Adverse Effects of Plasticizers and Pesticides on Female
Plasticizers and pesticides systemize its effects on adulthood either by mimicking, antagonizing, or having an impact on steroidal activity also along with hormonal disruptions. The aim of this...
Endocrine disruptors and female fertility: a review
Studies in mice have elucidated the mechanisms by which plasticizers negatively impact female fertility and IVF outcomes. After Patricia Hunt serendipitously discovered an increase in mouse oocyte aneuploidy associated with damaged plastic cages and water bottles in 1998, her group later elucidated a dose-dependent increase in oocyte aneuploidy
Phthalates may decrease fertility in female mice, study finds
A phthalate found in many plastic and personal care products may decrease fertility in female mice, a new study found. Researchers at the University of Illinois found that giving female...
FGF21 contributes to neuroendocrine control of female
In mammals, the mechanisms that inhibit fertility during starvation are complex and incompletely understood. Here we show that exposure of female mice to fibroblast growth factor 21 (FGF21), a fasting-induced hepatokine, mimics infertility secondary to starvation.
FGF21 contributes to neuroendocrine control of female
Eliminating Klb in the hindbrain of Tg(Fgf21) mice using a Phox2b-Cre line 23 did not restore estrus in any of the female mice (Supplementary Fig. 2). These results show that β-Klotho–mediated
