Plasticizers used in food-contact materials affect
Cells were exposed to the following plasticizers: DiNP, DiDP, DEGDB, TMCP or BPA at concentrations ranging from 0.01 to 25 μM, that were excluded to be toxic by visual analysis. 100 nM Rosiglitazone was used as a positive control. All the chemicals were dissolved in 100% DMSO as vehicle, and cells were exposed to a final concentration of 0.1% DMSO.
Plasticizers used in food-contact materials affect
Taken together, our results suggest that exposure to low, environmentally relevant doses of the plasticizers DiNP, DiDP, DEGDB and TMCP increase lipid accumulation in 3T3-L1 adipocytes, an effect likely mediated through activation of PPARγ and interference at different levels with the transcriptional cascade driving adipogenesis.
Phthalates in Food Packaging and Food Contact Applications
The FDA revoked authorizations for the food contact use of 23 phthalates and two other substances used as plasticizers, adhesives, defoaming agents, lubricants, resins, and slimicides.
Plasticizers used in food-contact materials affect
Recent studies suggest that exposure to some plasticizers, such as Bisphenol A (BPA), play a role in endocrine/metabolic dispruption and can affect lipid accumulation in adipocytes. Here, we investigated the adipogenic activity and nuclear receptor interactions of four plasticizers approved for the manufacturing of food-contact materials (FCMs
Plasticizers used in food-contact materials affect
Plasticizers used in food-contact materials affect adipogenesis in 3T3-L1 cells Valentina Pomatto, Erika Cottone, Paolo Cocci, Matteo Mozzicafreddo, Gilberto Mosconi, Erik Russel Nelson , Francesco Alessandro Palermo, Patrizia Bovolin
- Which plasticizers are used in food contact applications?
- ATBC, DEHA, DINCH, DOTP, and ESBO are used in food contact applications, are well-studied, and demonstrate low toxicity. Seven other plasticizers, 2EHESBO, ASE, CMCHA, DBT, DEHCH, PETV, and TOTM, have recent but limited food contact clearances.
- Do plasticizers have food contact clearances?
- Seven other plasticizers, 2EHESBO, ASE, CMCHA, DBT, DEHCH, PETV, and TOTM, have recent but limited food contact clearances. Assessments from CPSC, EFSA, and robust summaries in the REACH dossiers showed data gaps for some of these products; however, there were no concerns raised by the existing data.
- Which phthalate plasticizers are used in flexible PVC packaging?
- Human biomonitoring data are available for DINCH, DOTP, DEHA, DINA, and TOTM, and indicate that total exposures from all sources are below regulatory thresholds. Several non-ortho phthalate plasticizers, including ATBC, DEHA, DINCH, DOTP, and ESBO, are currently used in flexible PVC applications for food packaging and processing.
- Is human plasticizer exposure a risk factor for children?
- Taken all together and keeping in mind that the food path may be the major route for human plasticizer exposure, these data conclusively show very low levels of exposure. Consequently, no risk is concluded for the general population including sensitive subpopulations such as children based on these data.
- How do you calculate the daily intake of a plasticizer?
- The urinary concentrations of the metabolites (μg/g of creatinine) may be used to estimate the daily intake (DI, μg/kg bw/day) of the parent plasticizer using the methodology of David (2000) and Koch et al. (2003): DI = UE * CE * MW of the parent / (Fue * 1000 mg/g) Table 4. Exposure calculations from human biomonitoring data.
- What plasticizers does BASF manufacture?
- BASF manufactures a range of plasticizers, including ortho-phthalates, adipates, trimellitates, DINCH, and DOTP. The authors would like to thank Ruby Burner, Lauren Heine, and Uwe Storzum for their helpful insight during the preparation of the manuscript.
