Polymer-plasticizer compatibility during coating formulation
For the coating formulation to be successful and in order to produce flexible continuous film, the plasticizer should be compatible with the film forming polymer (i.e. high...
Polymer-plasticizer compatibility during coating formulation
Compatibility between a polymer and a plasticizer produces stable and homogeneous coating film. It is often characterized by a high miscibility between the plasticizer and the polymer blend. Polymer-plasticizer incompatibility influences not only the mechanical properties but also drug release [12], [13].
Polymer-plasticizer compatibility during coating formulation
N2 - During the formulation of solid dosage forms coating, plasticizers are added to the film forming polymer to improve the mechanical properties of the coating shell of the drug product.
Polymer-plasticizer compatibility during coating formulation
During the formulation of solid dosage forms coating, plasticizers are added to the film forming polymer to improve the mechanical properties of the coating shell of the drug product. For the coating formulation to be successful and in order to produce flexible continuous film, the plasticizer should be compatible with the film forming polymer
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aplasticizer(PolyvinylAlcohol(PVA))inaqueouspolymeric reducesdramatically thesegmentationor cracking thecoatinglmsupondrying. 3. Materials and methods 3.1. Materials Ourexperimentalstudyiselaboratedwithdifferentmaterials widelyusedinfoodandpharmaceuticalindustries.Thepolymers are; PVP:polyvinylpyrrolidone(K10),MCC:microcrystallinecel- lulose
- Is the plasticizer compatible with the film forming polymer?
- For the coating formulation to be successful and in order to produce flexible continuous film, the plasticizer should be compatible with the film forming polymer (i.e. high plasticizer-polymer miscibility in solid dispersion) (McGinity and Felton, 2008).
- Why is polymer-plasticizer incompatibility important?
- Compatibility between a polymer and a plasticizer produces stable and homogeneous coating film. It is often characterized by a high miscibility between the plasticizer and the polymer blend. Polymer-plasticizer incompatibility influences not only the mechanical properties but also drug release , .
- Do plasticizers affect polymeric coating properties?
- Various studies have been reported in the literature, investigating the effect of plasticizers on the properties of the final polymeric coating. Laboulfie et al. studied the effect of plasticizer on the mechanical resistance and thermal behavior of composite coating films.
- Does the plasticizer affect the thermal behavior of coating films?
- The impact of the plasticizer (PEG) on mechanical strength and thermal behavior of coating films (HPMC) was studied by Laboulfie et al. [7] Jarray et al. [8] additionally examined the affinity of the base polymers with the coating in both dry and aqueous systems. ... ...
- How to assess polymer-plasticizer compatibility?
- In this study, different methods for the assessment of polymer-plasticizers compatibility were proposed and compared. We have used Dmol3 and COSMO model to generate σ-profiles of the compounds. We have seen that σ-profiles give valuable information regarding polarities, hb-donors and hb-acceptors, wich allow to guess the solubility of compounds.
- Do opaque films have a compatibility between plasticizer and polymer?
- Opaque films usually reveal scarce compatibility between the plasticizer and the polymer : butyl chains increase apolarity of the plasticizer molecule and decrease the affinity with CA.
