Progress in the Removal of Di-[2-Ethylhexyl]-Phthalate as
Di- (2-Ethylhexyl)Phthalate In PVC blood bags, di- (2-ethylhexyl)phthalate (DEHP) has been used for more than 50 years as the plasticizer, resulting in a functional polymer with excellent characteristics such as inertness, flexibility, transparency, and high resistance to heat and chemicals.
Progress in the removal of di-[2-ethylhexyl]-phthalate as
Progress in the removal of di-[2-ethylhexyl]-phthalate as plasticizer in blood bags Polyvinylchloride (PVC) is used in blood component containers as well as in many other medical devices because it shows optimal inertness, durability, and resistance to heat and chemicals.
Progress in the Removal of Di-[2-Ethylhexyl]-Phthalate as
PVC thus needs to be plasticized, and di- (2-ethylhexyl)phthalate (DEHP) has been the most common plasticizer to produce the required flexibility to PVC. However, DEHP has been found to leach...
Reduction of exposure to plasticizers in stored red blood
Di-2-ethylhexyl-phthalate is the most common plasticizer in medical devices made of polyvinylchloride and is commonly found in soft bags storing red blood cell units. Di-2-ethylhexyl-phthalate and its degradation product mono-2-ethylhexyl-phthalate can migrate into human body fluids, for example, blood and tissues.
DEHT is a suitable plasticizer option for phthalate-free
Abstract. Background and objectives: Due to increasing concerns about possible endocrine-disrupting properties, the use of the plasticizer di (2-ethylhexyl) phthalate (DEHP) will be banned in future blood storage. Di (2-ethylhexyl) terephthalate (DEHT) provides sufficient red blood cell (RBC) quality during conventional blood bank storage.
- Is di (2-ethylhexyl) phthalate (DEHP) banned in blood storage bags?
- Accordingly, the European Union has banned the use of di (2-ethylhexyl) phthalate (DEHP) in blood storage bags beginning in May 2025. Despite the upcoming ban, non-DEHP blood bags result in increased hemolysis and shortened shelf life of RBCs.
- What is Di 2 ethylhexyl phthalate (DEHP)?
- Di (2-ethylhexyl) phthalate (DEHP) is a common plasticizer that is largely used for PVC blood bags. The migration of DEHP from medical devices into labile blood products (LBP) is a well-known situation.
- What is DEHP in PVC blood bags?
- In PVC blood bags, di- (2-ethylhexyl)phthalate (DEHP) has been used for more than 50 years as the plasticizer, resulting in a functional polymer with excellent characteristics such as inertness, flexibility, transparency, and high resistance to heat and chemicals.
- Is di (2-ethylhexyl) phthalate safe?
- However, phthalates are also endocrine disrupters that have been linked to increased risk of cancer and reproductive toxicity. Accordingly, the European Union has banned the use of di (2-ethylhexyl) phthalate (DEHP) in blood storage bags beginning in May 2025.
- How long does DEHP stay in a bag?
- Currently, second-generation additive solution such as PAGGS-M combined to DEHP-PVC allows up to 7 weeks of storage 10. The observation that DEHP leached to the blood components contained in the bag provoked an enormous amount of research into the physiochemical and toxicological behaviour of DEHP.
- Can phthalates be released from a medical device?
- As phthalates are not chemically bonded in the PVC, they can be released from the medical device during contact with the corresponding LBP along the storage life, then penetrate into the human fluid during transfusion.
