Providing Medical Device Solutions at MD&M West
When used in medical devices, plasticizers provide heightened flexibility to the device, allowing greater convenience and comfort. Citroflex B-6, a phthalate-free plasticizer specially formulated for PVC in blood transfusion products, offers an excellent alternative to DEHP with a comprehensive and clean toxicological profile.
PVC plasticizer alternatives for medical devices highlighted
PVC plasticizer alternatives for medical devices highlighted at MD&M West Chemical, processing, and design issues surrounding the replacement of phthalate plasticizers in PVC compounds for medical applications will be showcased during the forthcoming MD&M West exhibition and conference in Anaheim, CA.
Providing Medical Device Solutions at MD&M West; Phthalate
endotracheal tubes. When used in medical devices, plasticizers provide heightened flexibility to the . device, allowing greater convenience and comfort. Citroflex B-6, a phthalate-free plasticizer specially formulated for PVC in blood transfusion products, offers an excellent alternative to DEHP with a comprehensive and clean toxicological
The Long Goodbye to DEHP-plasticized PVC | mddionline.com
Also available are alternatives to PVC, including polypropylene blends and thermoplastics elastomers. However, while the performance of these compounds closely approaches that of PVC, they might require different design and manufacturing processes in order to be bonded to other substrates.
Migration of plasticizers from PVC medical devices
Alternatives to DEHP plasticizers are used in various PVC medical devices (MD) for infusion. As they are able to migrate from these MDs into infused solutions, they may come into contact with patient. Different and specific clinical parameters influence their migration in at-risk situations such as infusion.
- What are the alternative plasticizers for PVC MDS?
- This resulted in the commercialization of PVC MDs plasticized with the DEHP alternative plasticizers tri-octyl trimellitate (TOTM), di- (2-ethylhexyl) terephthalate (DEHT), di-isononyl cyclohexane-1,2-dicarboxylate (DINCH), di-isononyl phthalate (DINP), di- (2-ethylhexy) adipate (DEHA), and Acetyl tri- n -butyl citrate (ATBC).
- What is the best alternative plasticizer?
- Based on Table 1, the TOTM is the best alternative plasticizer. But since it received a low rating specifically in RBC hemolysis, DINCH could be considered for medical devices intended to hold blood for infusion or storage. The TOTM possesses the required attributes, and manufacturers can use it for other purposes.
- Are alternative plasticizers a viable alternative to PVC?
- There is, therefore, considerable interest in the development of materials that use alternative plasticizers or are fabricated from completely different biocompatible materials. Polyethylene (PE) offers significant advantages over PVC as no toxic waste products are formed upon incineration.
- Does plasticizer release a PVC MD into a simulant solution?
- We then tested the developed method on 32 PVC MDs used in our hospital and evaluated the plasticizer release from a PVC MD into a simulant solution during a 24 h migration test. The results showed a predominance of TOTM in PVC MDs accompanied by DEHP (<0.1% w/w), DEHT, and sometimes DEHA.
- What is the best plasticizer for medical grade PVC?
- Such alloys have enhanced electrical properties, high temperature stability, greater low temperature flexibility, and superior barrier properties. The most preferred plasticizer for medical grade PVC is DEHP commonly known as DOP even though other plasticizers could be used for specialized applications.
- What type of plasticizer is used in MD?
- Depending on the type of MD, the plasticizer content is very different. TOTM represents the majority plasticizer in extension lines and infusion sets, but is also present in the enteral nutrition line for one MD. This is surprising as it is not approved for food contact material in Europe. DINCH and ATBC are preferred in this type of MD.
